氢气（XEN）吸入可改善哮喘和 COPD 患者的气道炎症。
Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.
机构信息
From the Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
出版信息
QJM. 2020 Dec 1;113(12):870-875. doi: 10.1093/qjmed/hcaa164.
BACKGROUND
Hydrogen was proven to have anti-oxidative and anti-inflammation effects to various diseases.
AIM
We wish to investigate the acute effects of inhaled hydrogen on airway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD).
DESIGN
Prospective study.
METHODS
In total, 2.4% hydrogen containing steam mixed gas (XEN) was inhaled once for 45 min in 10 patients with asthma and 10 patients with COPD. The levels of granulocyte-macrophage colony stimulating factor, interferon-γ, interleukin-1β (IL-1β), IL-2, IL-4, IL-6 and so on in peripheral blood and exhaled breath condensate (EBC) before and after 'XEN' inhalation were measured.
RESULTS
45 minutes 'XEN' inhalation once decreased monocyte chemotactic protein 1 level in both COPD (564.70-451.51 pg/mL, P = 0.019) and asthma (386.39-332.76 pg/mL, P = 0.033) group, while decreased IL-8 level only in asthma group (5.25-4.49 pg/mL, P = 0.023). The level of EBC soluble cluster of differentiation-40 ligand in COPD group increased after inhalation (1.07-1.16 pg/mL, P = 0.031), while IL-4 and IL-6 levels in EBC were significantly lower after inhalation in the COPD (0.80-0.64 pg/mL, P = 0.025) and asthma (0.06-0.05 pg/mL, P = 0.007) group, respectively.
CONCLUSIONS
A single inhalation of hydrogen for 45 min attenuated inflammatory status in airways in patients with asthma and COPD.
背景
氢气已被证明对各种疾病具有抗氧化和抗炎作用。
目的
我们旨在研究吸入氢气对哮喘和慢性阻塞性肺疾病（COPD）患者气道炎症的急性影响。
设计
前瞻性研究。
方法
共 10 例哮喘患者和 10 例 COPD 患者吸入 2.4%氢气混合蒸汽（XEN），每次 45 分钟。在吸入“XEN”前后，测量外周血和呼出气冷凝液（EBC）中粒细胞-巨噬细胞集落刺激因子、干扰素-γ、白细胞介素-1β（IL-1β）、IL-2、IL-4、IL-6 等水平。
结果
一次性吸入 45 分钟“XEN”可降低 COPD（564.70-451.51pg/mL，P=0.019）和哮喘（386.39-332.76pg/mL，P=0.033）患者单核细胞趋化蛋白 1 的水平，而仅在哮喘组中降低白细胞介素-8 的水平（5.25-4.49pg/mL，P=0.023）。COPD 组 EBC 可溶性 CD40 配体水平在吸入后升高（1.07-1.16pg/mL，P=0.031），而 EBC 中的 IL-4 和 IL-6 水平在 COPD（0.80-0.64pg/mL，P=0.025）和哮喘（0.06-0.05pg/mL，P=0.007）组吸入后均显著降低。
结论
单次吸入氢气 45 分钟可减轻哮喘和 COPD 患者气道的炎症状态。
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