Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia; Internal Medicine Services, Ballarat Health Services, Ballarat, Victoria, Australia.
Trends Parasitol. 2020 Jun;36(6):560-570. doi: 10.1016/j.pt.2020.03.009. Epub 2020 Apr 22.
Plasmodium vivax is an important cause of malaria, associated with a significant public health burden. Whilst enhanced malaria-control activities have successfully reduced the incidence of Plasmodium falciparum malaria in many areas, there has been a consistent increase in the proportion of malaria due to P. vivax in regions where both parasites coexist. This article reviews the epidemiology and biology of P. vivax, how the parasite differs from P. falciparum, and the key features that render it more difficult to control and eliminate. Since transmission of the parasite is driven largely by relapses from dormant liver stages, its timely elimination will require widespread access to safe and effective radical cure.
间日疟原虫是疟疾的重要病因之一，对公共卫生造成了重大负担。虽然强化疟疾控制活动已成功降低了许多地区的恶性疟原虫疟疾发病率，但在同时存在这两种寄生虫的地区，间日疟原虫疟疾的比例持续上升。本文综述了间日疟原虫的流行病学和生物学特性，包括其与恶性疟原虫的区别，以及导致其更难以控制和消除的关键特征。由于该寄生虫的传播主要是由休眠肝期的复发驱动的，因此需要广泛获得安全有效的根治方法来及时消除它。
