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COVID-19, Clinical Trials, and QT-Prolonging Prophylactic Therapy in Healthy Subjects: First, Do No Harm.

作者信息

Gollob Michael H

机构信息

Inherited Arrhythmia and Cardiomyopathy Program, Arrhythmia Service, Division of Cardiology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

出版信息

J Am Coll Cardiol. 2020 Jun 30;75(25):3184-3186. doi: 10.1016/j.jacc.2020.05.008. Epub 2020 May 11.

DOI:10.1016/j.jacc.2020.05.008
PMID:32407770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7213956/
Abstract
摘要

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An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.一项国际性、多中心、基于证据的对报道引起先天性长 QT 综合征的基因的重新评估。
Circulation. 2020 Feb 11;141(6):418-428. doi: 10.1161/CIRCULATIONAHA.119.043132. Epub 2020 Jan 27.
2
Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.葡萄柚汁延长健康志愿者和长 QT 综合征患者的 QT 间期。
Heart Rhythm. 2019 Aug;16(8):1141-1148. doi: 10.1016/j.hrthm.2019.04.039. Epub 2019 May 8.
3
Loss-of-Function Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?功能丧失性变异：长QT综合征真正的单基因致病因素还是需要二次激发的促心律失常变异？
Circ Arrhythm Electrophysiol. 2017 Aug;10(8). doi: 10.1161/CIRCEP.117.005282.
4
Predicting the Unpredictable: Drug-Induced QT Prolongation and Torsades de Pointes.预测不可预测的：药物引起的 QT 间期延长和尖端扭转型室性心动过速。
J Am Coll Cardiol. 2016 Apr 5;67(13):1639-1650. doi: 10.1016/j.jacc.2015.12.063.
5
A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.一项大型候选基因研究确定KCNE1基因D85N多态性可能是药物诱导的尖端扭转型室速的一个调节因素。
Circ Cardiovasc Genet. 2012 Feb 1;5(1):91-9. doi: 10.1161/CIRCGENETICS.111.960930. Epub 2011 Nov 18.
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Azithromycin for prevention of exacerbations of COPD.阿奇霉素预防 COPD 加重。
N Engl J Med. 2011 Aug 25;365(8):689-98. doi: 10.1056/NEJMoa1104623.
7
High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment "failures".β受体阻滞剂在1型长QT综合征中的高效性：不依从性和延长QT间期药物对β受体阻滞剂治疗“失败”发生的影响。
Circulation. 2009 Jan 20;119(2):215-21. doi: 10.1161/CIRCULATIONAHA.108.772533. Epub 2008 Dec 31.
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Genetics of acquired long QT syndrome.获得性长QT综合征的遗传学
J Clin Invest. 2005 Aug;115(8):2025-32. doi: 10.1172/JCI25539.
9
Antiarrhythmic effects of azimilide in atrial fibrillation: efficacy and dose-response. Azimilide Supraventricular Arrhythmia Program 3 (SVA-3) Investigators.阿齐利特在心房颤动中的抗心律失常作用：疗效与剂量反应。阿齐利特室上性心律失常研究项目3（SVA - 3）研究者。
J Am Coll Cardiol. 2000 Sep;36(3):794-802. doi: 10.1016/s0735-1097(00)00773-7.