COVID-19, Clinical Trials, and QT-Prolonging Prophylactic Therapy in Healthy Subjects: First, Do No Harm.
作者信息
Gollob Michael H
机构信息
Inherited Arrhythmia and Cardiomyopathy Program, Arrhythmia Service, Division of Cardiology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
出版信息
J Am Coll Cardiol. 2020 Jun 30;75(25):3184-3186. doi: 10.1016/j.jacc.2020.05.008. Epub 2020 May 11.
Abstract
摘要
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An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.一项国际性、多中心、基于证据的对报道引起先天性长 QT 综合征的基因的重新评估。
Circulation. 2020 Feb 11;141(6):418-428. doi: 10.1161/CIRCULATIONAHA.119.043132. Epub 2020 Jan 27.
2
Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.葡萄柚汁延长健康志愿者和长 QT 综合征患者的 QT 间期。
Heart Rhythm. 2019 Aug;16(8):1141-1148. doi: 10.1016/j.hrthm.2019.04.039. Epub 2019 May 8.
3
Loss-of-Function Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?功能丧失性变异：长QT综合征真正的单基因致病因素还是需要二次激发的促心律失常变异？
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