Oymans Judith, van Keulen Lucien, Wichgers Schreur Paul J, Kortekaas Jeroen
Department of Virology, Wageningen Bioveterinary Research, Houtribweg 39, 8221 RA Lelystad, The Netherlands.
Laboratory of Virology, Wageningen University & Research, P.O. Box 16, 6700 AA Wageningen, The Netherlands.
Pathogens. 2020 May 13;9(5):373. doi: 10.3390/pathogens9050373.
Wesselsbron virus (WSLV) is a neglected, mosquito-borne flavivirus that is endemic to the African continent. The virus is teratogenic to ruminants and causes a self-limiting febrile illness in humans. Wesselsbron disease manifests with similar clinical signs and occurs in the same areas under the same climatic conditions as Rift Valley fever, which is therefore included in the differential diagnosis. Although the gross pathology of WSLV infection in pregnant ewes is reported in literature, the pathogenesis that leads to stillbirths, congenital malformations and abortion has remained undescribed. In the present study, pregnant ewes were inoculated with WSLV and subjected to detailed clinical- and histopathology 8 days later. The virus was mainly detected in foetal trophoblasts of the placenta and in neural progenitor cells, differentiated neurons, oligodendrocytes, microglia and astrocytes. Our study demonstrates that WSLV efficiently crosses the maternal-foetal interface and is highly neuroinvasive in the ovine foetus.
韦塞尔斯布朗病毒（WSLV）是一种被忽视的、由蚊子传播的黄病毒，在非洲大陆流行。该病毒对反刍动物具有致畸性，并可导致人类出现自限性发热疾病。韦塞尔斯布朗病表现出相似的临床症状，且与裂谷热在相同的气候条件下于相同地区发生，因此裂谷热被纳入鉴别诊断范围。尽管文献中报道了怀孕母羊感染WSLV的大体病理学情况，但导致死产、先天性畸形和流产的发病机制仍未得到描述。在本研究中，给怀孕母羊接种WSLV，8天后对其进行详细的临床和组织病理学检查。病毒主要在胎盘的胎儿滋养层细胞以及神经祖细胞、分化的神经元、少突胶质细胞、小胶质细胞和星形胶质细胞中被检测到。我们的研究表明，WSLV能够有效穿过母胎界面，并且在绵羊胎儿中具有高度神经侵袭性。
