School of Physics, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou, 510275, China.
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Sci Rep. 2020 May 15;10(1):8016. doi: 10.1038/s41598-020-64967-5.
Patient specific boluses can increase the skin dose distribution better for treating tumors located just beneath the skin with high-energy radiation than a flat bolus. We introduce a low-cost, 3D-printed, patient-specific bolus made of commonly available materials and easily produced using the "structure from motion" and a simple desktop 3D printing technique. Nine pictures were acquired with an iPhone camera around a head phantom. The 3D surface of the phantom was generated using these pictures and the "structure from motion" algorithm, with a scale factor calculated by a sphere fitting algorithm. A bolus for the requested position and shape based on the above generated surface was 3D-printed using ABS material. Two intensity modulated radiation therapy plans were designed to simulate clinical treatment for a tumor located under the skin surface with a flat bolus and a printed bolus, respectively. The planned parameters of dose volume histogram, conformity index (CI) and homogeneity index (HI) were compared. The printed bolus plan gave a dose coverage to the tumor with a CI of 0.817 compared to the CI of 0.697 for the plan with flat bolus. The HIs of the plan with printed bolus and flat bolus were 0.910 and 0.887, respectively.
与使用平板填充物相比,针对位于皮肤下的肿瘤,使用特定于患者的块状物进行高能放射治疗可以更好地增加皮肤剂量分布。我们引入了一种低成本、3D 打印、针对患者的块状物,由常见材料制成,使用“运动结构”和简单的桌面 3D 打印技术即可轻松制作。使用 iPhone 相机围绕头部模型拍摄了 9 张照片。使用这些照片和“运动结构”算法生成了模型的 3D 表面,并使用球体拟合算法计算了比例因子。基于上述生成的表面,使用 ABS 材料对所需位置和形状的块状物进行了 3D 打印。设计了两个调强放射治疗计划,分别使用平板填充物和打印的填充物来模拟针对位于皮肤表面下的肿瘤的临床治疗。比较了剂量体积直方图、适形指数(CI)和均匀性指数(HI)的计划参数。与平板填充物计划相比,打印的填充物计划使肿瘤的覆盖范围达到了 CI 为 0.817,而平板填充物计划的 CI 为 0.697。打印的填充物计划和平板填充物计划的 HI 分别为 0.910 和 0.887。