Lu Ying, Song Jianbo, Yao Xiaohong, An Meiwen, Shi Qinying, Huang Xiaobo
Laboratory of Biomaterial Surface and Interface, School of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, Shanxi Province, China.
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, Shanxi Province, China.
Int J Bioprint. 2021 Sep 22;7(4):414. doi: 10.18063/ijb.v7i4.414. eCollection 2021.
Bolus is a kind of auxiliary device used in radiotherapy for the treatment of superficial lesions such as skin cancer. It is commonly used to increase skin dose and overcome the skin-sparing effect. Despite the availability of various commercial boluses, there is currently no bolus that can form full contact with irregular surface of patients' skin, and incomplete contact would result in air gaps. The resulting air gaps can reduce the surface radiation dose, leading to a discrepancy between the delivered dose and planned dose. To avoid this limitation, the customized bolus processed by three-dimensional (3D) printing holds tremendous potential for making radiotherapy more efficient than ever before. This review mainly summarized the recent development of polymers used for processing bolus, 3D printing technologies suitable for polymers, and customization of 3D printing bolus. An ideal material for customizing bolus should not only have the feature of 3D printability for customization, but also possess radiotherapy adjuvant performance as well as other multiple compound properties, including tissue equivalence, biocompatibility, antibacterial activity, and antiphlogosis.
组织等效填充物是一种用于放射治疗皮肤癌等浅表病变的辅助装置。它通常用于增加皮肤剂量并克服皮肤保护效应。尽管有各种商用组织等效填充物，但目前没有一种能与患者皮肤的不规则表面完全贴合，不完全贴合会导致气隙。产生的气隙会降低表面辐射剂量，导致实际输送剂量与计划剂量之间出现差异。为避免这种限制，通过三维（3D）打印加工的定制组织等效填充物在使放射治疗比以往任何时候都更高效方面具有巨大潜力。本综述主要总结了用于加工组织等效填充物的聚合物的最新进展、适用于聚合物的3D打印技术以及3D打印组织等效填充物的定制。定制组织等效填充物的理想材料不仅应具有用于定制的3D可打印性，还应具备放射治疗辅助性能以及其他多种复合性能，包括组织等效性、生物相容性、抗菌活性和抗炎性。
