Department of Radiation Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
J Radiat Res. 2020 Nov 16;61(6):920-928. doi: 10.1093/jrr/rraa084.
The aim of the study was to evaluate the clinical feasibility of a 3D-print silica bolus for nasal NK/T-cell lymphoma radiation therapy. Intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) plans were designed using an anthropomorphic head phantom with a 3D-print silica bolus and other kinds of bolus used clinically, and the surface dose was measured by a metal oxide semiconductor field-effect transistor (MOSFET) dosimeter. Four nasal NK/T patients with or without 3D-print silica bolus were treated and the nose surface dose was measured using a MOSFET dosimeter during the first treatment. Plans for the anthropomorphic head phantom with 3D-print bolus have more uniform dose and higher conformity of the planning target volume (PTV) compared to other boluses; the homogeneity index (HI) and conformity index (CI) of the VMAT plan were 0.0589 and 0.7022, respectively, and the HI and CI of the IMRT plan were 0.0550 and 0.7324, respectively. The MOSFET measurement results showed that the surface dose of the phantom with 3D-print bolus was >180 cGy, and that of patients with 3D-print bolus was higher than patients without bolus. The air gap volume between the 3D-print bolus and the surface of patients was <0.3 cc. The 3D-print silica bolus fitted well on the patient's skin, effectively reducing air gaps between bolus and patient surface. Meanwhile, the 3D-print silica bolus provided patients with higher individuation, and improved the conformity and uniformity of the PTV compared to other kinds of boluses.
本研究旨在评估 3D 打印硅胶块在鼻腔 NK/T 细胞淋巴瘤放射治疗中的临床可行性。使用带有 3D 打印硅胶块的人体头部模型和临床上使用的其他类型的填充物设计强度调制放疗（IMRT）和容积调制弧形治疗（VMAT）计划，并使用金属氧化物半导体场效应晶体管（MOSFET）剂量仪测量表面剂量。对 4 例接受或不接受 3D 打印硅胶块的鼻腔 NK/T 患者进行治疗，在首次治疗期间使用 MOSFET 剂量仪测量鼻表面剂量。与其他填充物相比，带有 3D 打印填充体的人体头部模型计划具有更均匀的剂量和更高的靶区（PTV）适形性；VMAT 计划的均匀性指数（HI）和适形性指数（CI）分别为 0.0589 和 0.7022，IMRT 计划的 HI 和 CI 分别为 0.0550 和 0.7324。MOSFET 测量结果表明，带有 3D 打印填充体的模型的表面剂量>180 cGy，而带有 3D 打印填充体的患者的表面剂量高于没有填充体的患者。3D 打印填充体与患者表面之间的空气间隙体积<0.3 cc。3D 打印硅胶块贴合在患者皮肤上，有效减少了填充物和患者表面之间的气隙。同时，3D 打印硅胶块为患者提供了更高的个性化，与其他类型的填充物相比，提高了 PTV 的适形性和均匀性。
