National Center for Health Statistics, Division of Health and Nutrition Examination Surveys, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA
National Center for Health Statistics, Division of Health and Nutrition Examination Surveys, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA.
J Epidemiol Community Health. 2023 May;77(5):315-321. doi: 10.1136/jech-2022-219772. Epub 2023 Feb 27.
and are common parasites that infect humans globally. Our aim was to examine the relationship between and infection and cognition.
Multivariate logistic regression was used to test the association of and seropositivity on indices of cognitive function (a word list learning trial with delayed recall from the Consortium to Establish a Registry for Alzheimer's Disease, an animal fluency test (AFT) and a digit symbol substitution test (DSST)) among 2643 adults aged 60 years and older in the 2011-2014 National Health and Nutrition Examination Survey.
Seropositivity to or were both associated with lower scores in all three cognitive function measures examined in univariate analyses. Except for the DSST, these associations were not significant after adjustment for age, gender, race and Hispanic origin, poverty level, education, US birth status, depression and hypertension. On stratification to account for significant interactions, seropositivity was associated with worse scores on the AFT among those born outside the USA, worse scores on the DSST among those aged 60-69 years, female, Hispanic and with a high school diploma or less. Lower DSST scores with infection was greater for adults living below compared with at or above the poverty level.
Seropositivity to these parasites, particularly to , may be associated with diminished cognitive performance in certain subgroups of older adults.
和 是全球范围内常见的感染人类的寄生虫。我们的目的是研究 和 感染与认知之间的关系。
使用多变量逻辑回归来检验 2643 名年龄在 60 岁及以上的成年人中， 血清阳性和 血清阳性与认知功能指标（来自阿尔茨海默病协会建立登记册研究的单词列表学习试验、动物流畅性测试（AFT）和数字符号替代测试（DSST））之间的关联。
在单变量分析中， 或 血清阳性均与所有三种认知功能测试的得分降低相关。在调整年龄、性别、种族和西班牙裔血统、贫困水平、教育程度、美国出生状况、抑郁和高血压后，除 DSST 外，这些关联并不显著。在分层考虑到显著的相互作用时， 血清阳性与出生于美国以外的人 AFT 得分较差相关，60-69 岁的人 DSST 得分较差，女性、西班牙裔和高中文凭或以下的人 DSST 得分较差。与生活在贫困线以下的成年人相比， 感染的 DSST 得分较低的成年人更多。
这些寄生虫的血清阳性，特别是 ，可能与某些老年人群认知功能下降有关。
