School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Curr Diabetes Rev. 2021;17(2):107-121. doi: 10.2174/1573399816666200516173829.
The possible role of secondary metabolites in the management of diabetes is a great concern and constant discussion. This characteristic seems relevant and should be the subject of thorough discussion with respect to saponin.
The current data mainly focus on the impact of saponin in the treatment of type-II diabetes. The majority of studies emphasize on other secondary metabolites such as alkaloids and flavonoids, but very few papers are there representing the possible role of saponin as these papers express the narrow perspective of saponin phytoconstituents but lacking in providing the complete information on various saponin plants. The aim of the study was to summarize all available data concerning the saponin containing plant in the management of type-II diabetes.
All relevant papers on saponin were selected. This review summarizes the saponin isolation method, mechanism of action, clinical significance, medicinal plants and phytoconstituents responsible for producing a therapeutic effect in the management of diabetes.
The saponin is of high potential with structural diversity and inhibits diabetic complications along with reducing the hyperglycemia through different mechanisms thereby providing scope for improving the existing therapy and developing the novel medicinal agents for curing diabetes.
Saponins having potential therapeutic benefits and are theorized as an alternative medication in decreasing serum blood glucose levels in the patient suffering from diabetes.
次生代谢产物在糖尿病治疗中的可能作用是一个备受关注和持续讨论的话题。这种特性似乎很相关，应该就皂素进行深入讨论。
目前的数据主要集中在皂素治疗 II 型糖尿病方面的影响。大多数研究强调其他次生代谢产物，如生物碱和类黄酮，但很少有论文代表皂素的可能作用，因为这些论文仅表达了皂素植物成分的狭隘观点，而缺乏对各种含皂素植物的全面信息。本研究旨在总结所有关于含皂素植物在 II 型糖尿病管理中的可用数据。
选择了所有关于皂素的相关论文。本综述总结了皂素的分离方法、作用机制、临床意义、药用植物和负责产生治疗糖尿病效果的植物成分。
皂素具有结构多样性的巨大潜力，可抑制糖尿病并发症，同时通过不同机制降低高血糖，从而为改善现有治疗方法和开发治疗糖尿病的新型药物提供了空间。
皂素有潜在的治疗益处，被认为是治疗糖尿病患者血清血糖水平的替代药物。
