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迷迭香叶精油及其主要成分的局部抗炎活性及可能的作用机制

Topical Anti-Inflammatory Activity of Essential Oils of Rosc., Its Main Constituents, and Possible Mechanism of Action.

作者信息

Chandrakanthan Madhuvanthi, Handunnetti Shiroma M, Premakumara Galbada Sirimal Arachchige, Kathirgamanathar Selvaluxmy

机构信息

Industrial Technology Institute, Colombo-07, Sri Lanka.

Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo-03, Sri Lanka.

出版信息

Evid Based Complement Alternat Med. 2020 Apr 27;2020:2035671. doi: 10.1155/2020/2035671. eCollection 2020.

DOI:10.1155/2020/2035671
PMID:32419793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7204338/
Abstract

This study aimed at investigating the anti-inflammatory potential of essential oil from rhizome and leaf of Rosc. (ACEO) with the focus of its topical anti-inflammatory activity along with its dominant compounds 1,8-cineole and -terpineol using mouse ear edema model. ACEOs were analyzed by GC-MS. The anti-inflammatory activity was determined by studying the inhibition of overproduction of proinflammatory mediators-nitric oxide, reactive oxygen species, prostaglandins, cyclooxygenases, and cytokines induced by lipopolysaccharides in murine macrophages. Topical anti-inflammatory and antinociceptive activity was studied by 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin inflammation and formalin-induced pain model in mice, respectively. Rhizome oil has 1,8-cineole (31.08%), -terpineol (10.31%), and fenchyl acetate (10.73%) as major compounds whereas the ACEO from leaves has 1,8-cineole (38.45%), -terpineol (11.62%), and camphor (10%). ACEOs reduced the production of inflammatory mediators in a concentration-dependent manner. Further, ACEO and its major compounds reduced ear thickness, weight, myeloperoxidase, and cytokines significantly ( < 0.01) in mouse ear. Dose-dependent reduction in flinching and licking in both the phases of pain sensation concludes the topical analgesic effect. Our findings suggest the potency of topical use of ACEOs for inflammatory disease conditions.

摘要

本研究旨在调查迷迭香叶和根茎精油（ACEO）的抗炎潜力，重点关注其局部抗炎活性以及主要成分1,8 - 桉叶素和α - 萜品醇，采用小鼠耳肿胀模型进行研究。通过气相色谱 - 质谱联用仪（GC - MS）分析ACEO。通过研究脂多糖诱导的小鼠巨噬细胞中促炎介质一氧化氮、活性氧、前列腺素、环氧化酶和细胞因子的过量产生的抑制作用来确定抗炎活性。分别通过12 - O - 十四酰佛波醇 - 13 - 乙酸酯（TPA）诱导的小鼠皮肤炎症和福尔马林诱导的疼痛模型研究局部抗炎和镇痛活性。根茎油的主要成分有1,8 - 桉叶素（31.08%）、α - 萜品醇（10.31%）和乙酸小茴香酯（10.73%），而叶ACEO的主要成分有1,8 - 桉叶素（38.45%）、α - 萜品醇（11.62%）和樟脑（10%）。ACEO以浓度依赖的方式降低炎症介质的产生。此外，ACEO及其主要成分显著降低了小鼠耳部的厚度、重量、髓过氧化物酶和细胞因子水平（P < 0.01）。在疼痛感觉的两个阶段中，缩爪和舔舐的剂量依赖性降低证实了局部镇痛作用。我们的研究结果表明ACEO局部用于炎症性疾病具有潜力。

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