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肾小管坏死的关键基因：一项生物信息学分析

Key genes of renal tubular necrosis: a bioinformatics analysis.

作者信息

Lin Peng, Pan Yongqing, Chen Hang, Jiang Ling, Liao Yunhua

机构信息

Department of Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

出版信息

Transl Androl Urol. 2020 Apr;9(2):654-664. doi: 10.21037/tau.2019.11.24.

DOI:10.21037/tau.2019.11.24
PMID:32420172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7215026/
Abstract

BACKGROUND

To explore the key genes in renal tubular necrosis.

METHODS

Microarray datasets GSE69644, GSE27168, and GSE2027 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified and we performed functional enrichment analysis. The network of protein interaction and gene interaction was constructed, and the module analysis was conducted using Cytoscape.

RESULTS

A total of 543 DEGs and 13 hub genes were identified. The correlation analysis between the hub genes and the clinical characteristics of tubular necrosis indicated that the patients with high expression of SPAG5 and BIRC5 had better renal function. Patients with high expression of , and had poor renal function. Four of those hub genes participate in the cell cycle, apoptosis, and mismatch repair by regulating important genes in the pathway.

CONCLUSIONS

Our study suggests that , and participate in the cell cycle, apoptosis, and mismatch repair during renal tubule necrosis (RTN) and have an impact on renal function.

摘要

背景

探索肾小管坏死中的关键基因。

方法

从基因表达综合数据库下载微阵列数据集GSE69644、GSE27168和GSE2027。鉴定差异表达基因（DEG）并进行功能富集分析。构建蛋白质相互作用和基因相互作用网络，并使用Cytoscape进行模块分析。

结果

共鉴定出543个DEG和13个枢纽基因。枢纽基因与肾小管坏死临床特征的相关性分析表明，SPAG5和BIRC5高表达的患者肾功能较好。[此处原文缺失部分基因名称]高表达的患者肾功能较差。其中4个枢纽基因通过调节该途径中的重要基因参与细胞周期、凋亡和错配修复。

结论

我们的研究表明，[此处原文缺失部分基因名称]在肾小管坏死（RTN）过程中参与细胞周期、凋亡和错配修复，并对肾功能产生影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/03a8d4f18498/tau-09-02-654-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/df20875ccada/tau-09-02-654-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/860971f767ec/tau-09-02-654-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/a5d3da5fd3b3/tau-09-02-654-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/0ec1871de8d7/tau-09-02-654-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/d7a14465c798/tau-09-02-654-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/c0154126dc1a/tau-09-02-654-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/c4fc3ba51230/tau-09-02-654-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/aade47d7c302/tau-09-02-654-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/03a8d4f18498/tau-09-02-654-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/df20875ccada/tau-09-02-654-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/860971f767ec/tau-09-02-654-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/a5d3da5fd3b3/tau-09-02-654-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/0ec1871de8d7/tau-09-02-654-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/d7a14465c798/tau-09-02-654-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/c0154126dc1a/tau-09-02-654-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/c4fc3ba51230/tau-09-02-654-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/aade47d7c302/tau-09-02-654-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5fc/7215026/03a8d4f18498/tau-09-02-654-f9.jpg

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