This systematic review and meta-analysis study aimed to investigate the association between exposure to road traffic noise (RTN) and myocardial infarction (MI). Of 681 studies found by searching in databases, including Scopus, Web of Science, Embase, and PubMed on November 29, 2019, the number of 13 studies, including seven cohort, five case-control, and one cross-sectional studies with 1,626,910 participants and 45,713 cases of MI was included. The pooled relative risk (RR) and 95% confidence interval (CI) of MI were calculated using a random-effect model across studies. Heterogeneity measures by reporting the I-square index. Subgroup analysis according to the designs and sensitivity analysis based on the Jackknife approach was performed. We observed in the eight studies the association was investigated in different noise exposure groups and in the 10 studies (including two conference papers) the risk of MI was provided per specific unit increment of RTN. We ran two independent types of meta-analyses involving a categorical analysis (comparing the highest and the lowest category of noise exposure groups) and an exposure-response analysis (the risk of MI per 10-dB increment of RTN). The pooled RR (95% CI) of MI for the categorical and exposure-response meta-analyses was calculated 1.03 (0.93, 1.13) and 1.02 (1.00, 1.05), respectively. For both types of meta-analyses, subgroup analysis indicates a significant association in the studies with case-control and cross-sectional designs but not cohort studies. For the exposure-response meta-analysis, a significantly greater risk of MI was observed after excluding the two conference papers (RR = 1.03 and 95% CI = 1.00, 1.05) and by further excluding the studies provided originally the risk of MI only for the categorical analysis (RR = 1.02 and 95% CI = 1.01, 1.03). We did not show a significant publication bias across studies. In conclusion, our study suggests a significant odds of association between exposure to RTN and the risk of MI.