韩国商品蛋鸡源环丙沙星耐药分离株中质粒介导喹诺酮耐药决定因子及 ()--的流行与特征。
Prevalence and Characterization of Plasmid-Mediated Quinolone Resistance Determinants and ()-- in Ciprofloxacin-Resistant Isolates from Commercial Layer in Korea.
机构信息
College of Veterinary Medicine and Zoonoses Research Institute, Kyungpook National University, Daegu 41566, Republic of Korea.
Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, MS 39762, USA.
出版信息
J Microbiol Biotechnol. 2020 Aug 28;30(8):1180-1183. doi: 10.4014/jmb.2003.03058.
Abstract
The prevalence and characterization of plasmid-mediated quinolone resistance (PMQR) determinants in ciprofloxacin-resistant isolated from a Korean commercial layer farm were studied. A total of 45 ciprofloxacin-resistant isolates were recovered and all isolates were multidrug-resistant. Eight isolates have the PMQR genes , , and , and seven isolates exhibited double amino acid exchange at both and , and have high fluoroquinolone minimum inhibitory concentrations. Five transconjugants demonstrated transferability of PMQR and β-lactamase genes and similar antimicrobial resistance. Because PMQR genes in isolates from commercial layer chickens could enter the food supply and directly affect humans, control of ciprofloxacin resistance is needed.
摘要
本研究旨在调查韩国商业蛋鸡场分离的环丙沙星耐药 中质粒介导喹诺酮耐药（PMQR）决定因子的流行情况和特征。共回收 45 株环丙沙星耐药 ，所有分离株均为多重耐药株。8 株分离株携带 PMQR 基因 、 、 和 ，7 株分离株在 和 均表现出双重氨基酸置换，且对氟喹诺酮类最低抑菌浓度较高。5 株转导子表现出 PMQR 和β-内酰胺酶基因的可转移性和相似的抗菌药物耐药性。由于商业蛋鸡场 分离株中的 PMQR 基因可能进入食物供应并直接影响人类，因此需要控制环丙沙星耐药性。
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