Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
J Infect Chemother. 2020 Aug;26(8):851-853. doi: 10.1016/j.jiac.2020.05.002. Epub 2020 May 8.
We here report a case of coronavirus disease-19 (COVID-19) in Japan in which the initial throat swab polymerase chain reaction result was negative The possibility of false-negative results in the early phase of disease suggest reconsideration of the feasibility of a community or national infection control framework to prevent transmission. We recommend establishing an alternative feasible system, such as self-isolation by contact history in non-endemic community and by symptoms in endemic community, not relying on the PCR examination, to minimize this ongoing COVID-19 outbreak. Further rapid accumulation of knowledge including incubation period, clinical course and types of transmission is warranted to control this outbreak.
我们在此报告一例在日本发生的 2019 冠状病毒病（COVID-19）病例，其初始咽喉拭子聚合酶链反应结果为阴性。疾病早期出现假阴性结果的可能性提示需要重新考虑社区或国家感染控制框架的可行性，以防止传播。我们建议建立一种替代的可行系统，例如在非流行社区根据接触史、在流行社区根据症状进行自我隔离，而不依赖于 PCR 检查，以尽量减少目前的 COVID-19 爆发。进一步快速积累包括潜伏期、临床病程和传播类型在内的知识对于控制此次疫情是必要的。
