Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York.
The Columbia University Renal Epidemiology Group, New York, New York.
Clin J Am Soc Nephrol. 2020 Aug 7;15(8):1174-1178. doi: 10.2215/CJN.05170420. Epub 2020 May 18.
Outcomes of kidney transplant recipients diagnosed with coronavirus disease 2019 as outpatients have not been described.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We obtained clinical data for 41 consecutive outpatient kidney transplant recipients with known or suspected coronavirus disease 2019. Chi-squared and Wilcoxon rank sum tests were used to compare characteristics of patients who required hospitalization versus those who did not.
Of 41 patients, 22 (54%) had confirmed coronavirus disease 2019, and 19 (46%) were suspected cases. Patients most commonly reported fever (80%), cough (56%), and dyspnea (39%). At the end of follow-up, 13 patients (32%) required hospitalization a median of 8 days (range, 1-16) after symptom onset, and 23 (56%) had outpatient symptom resolution a median of 12 days (4-23) after onset. Patients who required hospitalization were more likely to have reported dyspnea (77% versus 21%, =0.003) and had higher baseline creatinine (median, 2.0 versus 1.3 mg/dl, =0.02), but there were no other differences between groups.
In an early cohort of outpatient kidney transplant recipients with known or suspected coronavirus disease 2019, many had symptomatic resolution without requiring hospitalization.
尚未描述在门诊被诊断为 2019 年冠状病毒病(COVID-19)的肾移植受者的结局。
设计、地点、参与者和测量方法:我们获得了 41 例连续门诊肾移植受者的已知或疑似 COVID-19 的临床数据。使用卡方检验和 Wilcoxon 秩和检验比较需要住院与不需要住院的患者的特征。
41 例患者中,22 例(54%)有确诊 COVID-19,19 例(46%)为疑似病例。患者最常报告的症状为发热(80%)、咳嗽(56%)和呼吸困难(39%)。在随访结束时,13 例患者(32%)在症状出现后中位 8 天(范围 1-16 天)需要住院,23 例患者(56%)在症状出现后中位 12 天(4-23 天)门诊症状缓解。需要住院的患者更有可能报告呼吸困难(77%对 21%,=0.003),并且基线肌酐更高(中位数 2.0 对 1.3 mg/dl,=0.02),但两组之间没有其他差异。
在一个已知或疑似 COVID-19 的门诊肾移植受者的早期队列中,许多患者在无需住院的情况下症状得到缓解。