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大鼠(褐家鼠)的酯酶-13及其与家鼠(小家鼠)酯酶-3的同源性。

Esterase-13 of the rat (Rattus norvegicus) and its homology with esterase-3 of the house mouse (Mus musculus).

作者信息

Scholze M, Günther E, von Deimling O

出版信息

Comp Biochem Physiol B. 1984;78(3):713-8. doi: 10.1016/0305-0491(84)90123-8.

Abstract

A new allele of esterase-13 was detected in various laboratory inbred strains of Rattus norvegicus and designated Es-13c. The activity of ES-13 towards a range of chromogenic substrates, inhibitor profile, isoelectric points and retardation coefficients on polyacrylamide gel electrophoresis were determined. The organ specific expression of ES-13 alleles was investigated and it was shown that kidney homogenates contained a factor which modified the liver enzyme banding pattern in vitro. The features of ES-13 from the rat indicated homology between this esterase and ES-3 from the house mouse, Mus musculus domesticus.

摘要

在多种挪威大鼠实验室近交系中检测到酯酶-13的一个新等位基因,并将其命名为Es-13c。测定了ES-13对一系列生色底物的活性、抑制剂谱、等电点以及在聚丙烯酰胺凝胶电泳上的迁移系数。研究了ES-13等位基因的器官特异性表达,结果表明肾匀浆中含有一种能在体外改变肝脏酶条带模式的因子。大鼠ES-13的特征表明该酯酶与家鼠(小家鼠)的ES-3具有同源性。

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