Conde-Sampayo Alejandro, Lorenzo-González María, Fernández-Villar Alberto, Barros-Dios Juan Miguel, Ruano-Ravina Alberto
Preventive Medicine Unit, Ourense University Teaching Hospital Complex, Ourense, Spain.
Pneumology Unit, Vigo University Teaching Hospital Complex, Vigo, Spain.
Int J Chron Obstruct Pulmon Dis. 2020 Apr 28;15:939-948. doi: 10.2147/COPD.S245982. eCollection 2020.
The aim of this study was to analyse the relationship between exposure to residential radon and chronic obstructive pulmonary disease (COPD) by means of a systematic review.
A search was conducted in PubMed and OVID for papers making reference to the radon-COPD relationship. No search filters were applied, whether by date of publication, study type or sample size. All studies not written in English or Spanish were discarded.
A total of 174 and 57 papers were found in PubMed and OVID, respectively: of these, 13 (11 on miners and 2 on the general population) fulfilled the inclusion criteria. Only four of the studies on cohorts of miners analysed COPD as a specific disease, and only one reported statistically significant results. In addition, many of these studies lacked information on tobacco use among miners. In contrast, studies conducted on the general public showed an association between mortality and hospital admissions, on the one hand, and residential radon on the other.
There are not enough studies to provide a basis for confirming or ruling out an association between radon exposure and COPD. Nonetheless, the most recent general population studies point to evidence of a possible association. In view of the heterogeneity of available studies, it is impossible to say whether this gas may or may not affect COPD morbidity and mortality, until such a time as further studies are carried out.
本研究旨在通过系统评价分析住宅氡暴露与慢性阻塞性肺疾病（COPD）之间的关系。
在PubMed和OVID中检索提及氡与COPD关系的论文。未应用任何检索过滤器，无论按出版日期、研究类型还是样本量。所有非英文或西班牙文撰写的研究均被排除。
在PubMed和OVID中分别找到174篇和57篇论文：其中13篇（11篇关于矿工，2篇关于普通人群）符合纳入标准。关于矿工队列的研究中，只有4篇将COPD作为特定疾病进行分析，且只有1篇报告了具有统计学意义的结果。此外，这些研究中有许多缺乏矿工吸烟情况的信息。相比之下，针对普通公众开展的研究表明，一方面死亡率和住院率与另一方面住宅氡之间存在关联。
没有足够的研究为确认或排除氡暴露与COPD之间的关联提供依据。尽管如此，最新的普通人群研究指向了可能存在关联的证据。鉴于现有研究的异质性，在开展进一步研究之前，无法确定这种气体是否会影响COPD的发病率和死亡率。
