电动表面电荷改变外加电场引起的膜电位变化。
Electromobile surface charge alters membrane potential changes induced by applied electric fields.
作者信息
Gross D
机构信息
Department of Biochemistry, University of Massachusetts, Amherst 01003.
出版信息
Biophys J. 1988 Nov;54(5):879-84. doi: 10.1016/S0006-3495(88)83024-8.
Abstract
The relation between extracellular electric fields and changes in membrane potential that such fields directly induce has previously been described both theoretically and experimentally. It is clearly established that extracellular electric-field-induced membrane potential changes are well described by Poisson's equation of electrostatics. A modification of this simple theory to include effects of the electric-field-induced redistribution of charged cell surface components is introduced and is shown to produce major alterations in calculated membrane potential changes over times of the order of minutes to hours. Implications for biological systems which respond to extracellular electric fields are discussed.
摘要
细胞外电场与这种电场直接诱导的膜电位变化之间的关系，此前已在理论和实验上都有过描述。很明显，静电学的泊松方程能够很好地描述细胞外电场诱导的膜电位变化。本文引入了对这一简单理论的修正，以纳入电场诱导的带电细胞表面成分重新分布的影响，并表明这会在几分钟到几小时的时间尺度上对计算出的膜电位变化产生重大改变。文中还讨论了其对响应细胞外电场的生物系统的影响。
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