Rochwerg Bram, Parke Rachael, Murthy Srinivas, Fernando Shannon M, Leigh Jeanna Parsons, Marshall John, Adhikari Neill K J, Fiest Kirsten, Fowler Rob, Lamontagne François, Sevransky Jonathan E
Department of Medicine, McMaster University, Hamilton, ON, Canada.
Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Crit Care Explor. 2020 Apr 29;2(4):e0098. doi: 10.1097/CCE.0000000000000098. eCollection 2020 Apr.
Although the amount of information generated during this most recent coronavirus disease 2019 pandemic is enormous, much is of uncertain trustworthiness. This review summaries the many potential sources of information that clinicians turn to during pandemic illness, the challenges associated with performing methodologically sound research in this setting and potential approaching to conducting well done research during a health crisis.
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Pandemics and healthcare crises provide extraordinary opportunities for the rapid generation of reliable scientific information but also for misinformation, especially in the early phases, which may contribute to public hysteria. The best way to combat misinformation is with trustworthy data produced by healthcare researchers. Although challenging, research can occur during pandemics and crises and is facilitated by advance planning, governmental support, targeted funding opportunities, and collaboration with industry partners. The coronavirus disease 2019 research response has highlighted both the dangers of misinformation as well as the benefits and possibilities of performing rigorous research during challenging times.
尽管在最近的2019冠状病毒病大流行期间产生的信息量巨大，但其中许多信息的可信度存疑。本综述总结了临床医生在大流行疾病期间所求助的众多潜在信息来源、在此背景下开展方法合理的研究面临的挑战以及在健康危机期间进行高质量研究的潜在方法。
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大流行和医疗保健危机既为快速生成可靠的科学信息提供了绝佳机会，也为错误信息的传播创造了条件，尤其是在早期阶段，这可能会导致公众恐慌。对抗错误信息的最佳方式是依靠医疗保健研究人员提供的可信数据。尽管存在挑战，但在大流行和危机期间仍可开展研究，提前规划、政府支持、有针对性的资金机会以及与行业伙伴的合作有助于研究的进行。2019冠状病毒病的研究应对措施既凸显了错误信息的危害，也展现了在困难时期进行严谨研究的益处和可能性。
