Children & Young People's Unit, The Royal Marsden NHS Foundation Trust, London, UK.
Department of Paediatric Oncology, University Hospital Centre of São João, Porto, Portugal.
Pediatr Blood Cancer. 2020 Jul;67(7):e28407. doi: 10.1002/pbc.28407. Epub 2020 May 19.
Little is known about pseudoprogression in brain tumours other than gliomas. A 9-year-old male child with a pineal teratoma/germinoma underwent surgical resection followed by adjuvant chemo-radiotherapy. The magnetic resonance imaging scan 4 months post-radiotherapy showed a contrast-enhancing lesion within the surgical cavity suspicious of recurrence. These radiological findings subsequently resolved without any specific intervention. The child continues in remission 2 years post-treatment. This case illustrates the occurrence of pseudoprogression post-radiotherapy in intracranial GCT and highlights an unmet need for greater implementation of functional imaging techniques in paediatric neuro-oncology to avoid undue discontinuation of effective treatments or inappropriate enrolment in clinical trials.
除了神经胶质瘤之外，人们对脑瘤中的假性进展知之甚少。一名 9 岁男性松果体畸胎瘤/生殖细胞瘤患儿接受了手术切除，随后进行了辅助化疗和放疗。放疗后 4 个月的磁共振成像扫描显示手术腔内有一个增强的疑似复发的病变。这些影像学发现随后未经任何特殊干预而消退。患儿在治疗后 2 年持续缓解。该病例说明了放疗后颅内 GCT 中出现假性进展，并强调了在儿科神经肿瘤学中需要更大程度地实施功能成像技术，以避免不必要地停止有效治疗或不恰当地参加临床试验。
