University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713 GZ Groningen, the Netherlands; King Saud University, College of Applied Medical Science, Department of Radiological Sciences, Riyadh, Saudi Arabia.
University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.
J Control Release. 2020 Aug 10;324:303-316. doi: 10.1016/j.jconrel.2020.05.020. Epub 2020 May 16.
Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promising new application. However, the mechanism of BBB opening by FUS remains unclear. This review focuses on the use of FUS to open the BBB for enhancing drug delivery and investigating how Positron Emission Tomography (PET) provides insight into the underlying mechanism.
聚焦超声（FUS）是一种用于治疗多种疾病的微创技术，包括与结肠、子宫、前列腺和大脑相关的疾病。尽管它主要用于消融手术，但 FUS 打开血脑屏障（BBB）的能力为其提供了一种有前途的新应用。然而，FUS 打开 BBB 的机制尚不清楚。本综述重点介绍了 FUS 用于打开 BBB 以增强药物输送的应用，并探讨了正电子发射断层扫描（PET）如何提供对潜在机制的深入了解。
