Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.
Sensors (Basel). 2020 May 16;20(10):2846. doi: 10.3390/s20102846.
This work presents a magnetic-driven deterministic lateral displacement (m-DLD) microfluidic device. A permanent magnet located at the outlet of the microchannel was used to generate the driving force. Two stages of mirrored round micropillar array were designed for the separation of magnetic beads with three different sizes in turn. The effects of the forcing angle and the inlet width of the micropillar array on the separating efficiency were studied. The m-DLD device with optimal structure parameters shows that the separating efficiencies for the 10 μm, 20 μm and 40 μm magnetic beads are 87%, 89% and 94%, respectively. Furthermore, this m-DLD device was used for antibody recognition and separation among a mixture solution of antibodies. The trajectories of different kinds of magnetic beads coupled with different antigens showed that the m-DLD device could realize a simple and low-cost diagnostic test.
本文提出了一种磁驱动确定性侧向位移（m-DLD）微流控装置。位于微通道出口处的永磁体用于产生驱动力。设计了两级镜像圆形微柱阵列，用于依次分离三种不同尺寸的磁珠。研究了外加力角和微柱阵列入口宽度对分离效率的影响。具有最佳结构参数的 m-DLD 装置表明，对于 10 μm、20 μm 和 40 μm 磁珠的分离效率分别为 87%、89%和 94%。此外，该 m-DLD 装置还用于抗体识别和分离抗体混合物溶液。不同种类的磁珠与不同抗原结合的轨迹表明，m-DLD 装置可以实现简单且低成本的诊断测试。
