Kasraeian Maryam, Zare Marjan, Vafaei Homeira, Asadi Nasrin, Faraji Azam, Bazrafshan Khadijeh, Roozmeh Shohreh
Maternal-fetal medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
J Matern Fetal Neonatal Med. 2022 May;35(9):1652-1659. doi: 10.1080/14767058.2020.1763952. Epub 2020 May 19.
The new SARS-CoV-2 originated from Wuhan, China is spreading rapidly worldwide. A number of SARS-CoV-2 positive pregnant women have been reported. However, more information is still needed on the pregnancy outcome and the neonates regarding COVID-19 pneumonia.
A systematic search was done and nine articles on COVID-19 pneumonia and SARS-CoV-2 positive pregnant women were extracted. Some maternal-fetal characteristics were extracted to be included in the meta-analysis
The present meta-analysis was conducted on 87 SARS-CoV-2 positive pregnant women. Almost 65% of the patients reported a history of exposure to an infected person, 78% suffered from mild or moderate COVID-19, 99.9% had successful termination, 86% had cough, and 68% had fever ( = .022 and < .001). The overall proportions of vertical transmission, still birth, and neonatal death were zero, 0.002, and, 0.002, respectively ( = 1, = .86, and = .89, respectively). The means of the first- and fifth-minute Apgar scores were 8.86 and 9, respectively ( < .001 for both). The confounding role of history of underlying diseases with an estimated overall proportion of 33% ( = .03) resulted in further investigations due to sample size limitation. A natural history of COVID-19 pneumonia in the adult population was presented, as well.
Currently, no evidence of vertical transmission has been suggested at least in late pregnancy. No hazards have been detected for fetuses or neonates. Although pregnant women are at an immunosuppressive state due to the physiological changes during pregnancy, most patients suffered from mild or moderate COVID-19 pneumonia with no pregnancy loss, proposing a similar pattern of the clinical characteristics of COVID-19 pneumonia to that of other adult populations.
源自中国武汉的新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）正在全球迅速传播。已有多例SARS-CoV-2阳性孕妇的报道。然而，关于新型冠状病毒肺炎（COVID-19）孕妇的妊娠结局及新生儿情况，仍需更多信息。
进行系统检索，提取9篇关于COVID-19肺炎及SARS-CoV-2阳性孕妇的文章。提取一些母婴特征纳入荟萃分析。
本荟萃分析纳入87例SARS-CoV-2阳性孕妇。近65%的患者报告有接触感染者的病史，78%患有轻度或中度COVID-19，99.9%成功分娩，86%有咳嗽症状，68%有发热症状（P = 0.022和P < 0.001）。垂直传播、死产和新生儿死亡的总体比例分别为零、0.002和0.002（P分别为1、0.86和0.89）。1分钟和5分钟阿氏评分的平均值分别为8.86和9（两者P均 < 0.001）。由于样本量限制，潜在疾病史的混杂作用估计总体比例为33%（P = 0.03），需进一步研究。同时也呈现了COVID-19肺炎在成年人群中的自然病程。
目前，至少在妊娠晚期未发现垂直传播的证据。未检测到对胎儿或新生儿有危害。尽管孕妇因孕期生理变化处于免疫抑制状态，但大多数患者患有轻度或中度COVID-19肺炎且无妊娠丢失，提示COVID-19肺炎的临床特征与其他成年人群相似。
