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Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience.COVID-19 患者的依库珠单抗治疗：来自 ASL Napoli 2 Nord 真实经验的初步结果。
Eur Rev Med Pharmacol Sci. 2020 Apr;24(7):4040-4047. doi: 10.26355/eurrev_202004_20875.
2
Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19.新型冠状病毒肺炎患者的凝血障碍与抗磷脂抗体
N Engl J Med. 2020 Apr 23;382(17):e38. doi: 10.1056/NEJMc2007575. Epub 2020 Apr 8.
3
Clinical Characteristics of Coronavirus Disease 2019 in China.《中国 2019 年冠状病毒病临床特征》
N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.
4
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population.健康白种人群中补体活性和补体水平的年龄和性别相关变化。
Front Immunol. 2018 Nov 20;9:2664. doi: 10.3389/fimmu.2018.02664. eCollection 2018.
5
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.补体激活参与严重急性呼吸综合征冠状病毒发病机制。
mBio. 2018 Oct 9;9(5):e01753-18. doi: 10.1128/mBio.01753-18.
6
Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV.阻断 C5a-C5aR 轴可减轻 hDPP4 转基因感染 MERS-CoV 的小鼠肺部损伤。
Emerg Microbes Infect. 2018 Apr 24;7(1):77. doi: 10.1038/s41426-018-0063-8.
7
Complementopathies.补体病
Blood Rev. 2017 Jul;31(4):213-223. doi: 10.1016/j.blre.2017.02.003. Epub 2017 Feb 6.
8
The role of C5a in acute lung injury induced by highly pathogenic viral infections.C5a在高致病性病毒感染所致急性肺损伤中的作用。
Emerg Microbes Infect. 2015 May;4(5):e28. doi: 10.1038/emi.2015.28. Epub 2015 May 6.
9
The complement system: history, pathways, cascade and inhibitors.补体系统：历史、途径、级联反应及抑制剂
Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):103-11. doi: 10.1556/EuJMI.2.2012.2.2. Epub 2012 Jun 13.
10
Incidence and outcomes of acute lung injury.急性肺损伤的发病率及转归
N Engl J Med. 2005 Oct 20;353(16):1685-93. doi: 10.1056/NEJMoa050333.

Could severe COVID-19 be considered a complementopathy?

作者信息

Chatzidionysiou Katerina, Svenungsson Elisabet, Faustini Francesca

机构信息

Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet Department of Medicine Solna, Stockholm, Sweden

Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet Department of Medicine Solna, Stockholm, Sweden.

出版信息

Lupus Sci Med. 2020 May;7(1). doi: 10.1136/lupus-2020-000415.

DOI:10.1136/lupus-2020-000415
PMID:32430402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7246101/
Abstract
摘要