Department of Chemistry, University of Science & Technology of China, Hefei, Anhui 230026, China.
J Mater Chem B. 2020 Jun 24;8(24):5178-5183. doi: 10.1039/d0tb00280a.
This review focuses on emerging applications of surface-enhanced Raman spectroscopy (SERS) optical nanosensors for miRNA analysis, in which the key enhancement factors of the SERS signal, i.e. SERS-active substrates, SERS nanoprobes and nano-assembly strategy, are emphasized. This article includes many nanomaterials for miRNA analysis by the SERS technique. We summarize these reported nanomaterials mainly according to their function in the miRNA assay biosensor. We also briefly summarize the research progress of these nanomaterials in SERS detection of intracellular miRNA. Finally, we discussed the prospect and limitations of SERS nanosensors for analyzing miRNA.
这篇综述重点介绍了表面增强拉曼光谱（SERS）光学纳米传感器在 miRNA 分析中的新兴应用，其中强调了 SERS 信号的关键增强因素，即 SERS 活性基底、SERS 纳米探针和纳米组装策略。本文介绍了通过 SERS 技术分析 miRNA 的多种纳米材料。我们主要根据这些纳米材料在 miRNA 分析生物传感器中的功能对其进行了总结。我们还简要总结了这些纳米材料在 SERS 检测细胞内 miRNA 方面的研究进展。最后，我们讨论了用于分析 miRNA 的 SERS 纳米传感器的前景和局限性。
