Feng Lili, Gai Shili, He Fei, Yang Piaoping, Zhao Yanli
Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, People's Republic of China.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
ACS Nano. 2020 Jun 23;14(6):7245-7258. doi: 10.1021/acsnano.0c02458. Epub 2020 May 28.
Ultrasound (US)-assisted oncotherapy has aroused extensive attention due to its capacities to conquer significant restrictions covering short tissue penetration depth and high phototoxicity in photoinduced therapy. We herein developed a class of pure-phase perovskite-type bimetallic oxide, namely, bismuth ferrite nanocatalysts (BFO NCs), for multimodality imaging-guided and US-enhanced chemodynamic therapy (CDT) against malignant tumors. As-prepared BFO nanoparticles with poly(ethylene glycol)-grafted phosphorylated serine (pS-PEG) modification exhibit satisfactory physiological stability and biocompatibility. The BFO NCs also present high fluorescence emission within the second near-infrared region when irradiated with an 808 nm laser. Intriguingly, the BFO NCs demonstrate highly efficient US-enhanced generation of hydroxyl free radicals, as the cavitation bubbles produced by US trigger partial grievous turbulence and promote the transfer rate of the Fenton reagents. Thus, the BFO NCs enable effective inhibition of tumor growth assisted by external US, and the treatment efficacy can be monitored by computer tomography, magnetic resonance, and fluorescence imaging. Meanwhile, HO and US, as a double logic gate, activate the BFO NCs to trigger the iron-catalyzed and US-enhanced CDT with high specificity and treatment efficiency. Therefore, the BFO NCs as a theranostic agent with an enhanced chemodynamic therapeutic effect assisted by external US and a multimodality imaging capacity are put forward, which show a promising prospect for noninvasive chemodynamic oncotherapy.
超声（US）辅助肿瘤治疗因其能够克服光诱导治疗中组织穿透深度短和光毒性高的重大限制而引起了广泛关注。我们在此开发了一类纯相钙钛矿型双金属氧化物，即铋铁氧体纳米催化剂（BFO NCs），用于多模态成像引导和US增强的针对恶性肿瘤的化学动力疗法（CDT）。制备的带有聚（乙二醇）接枝磷酸化丝氨酸（pS-PEG）修饰的BFO纳米颗粒表现出令人满意的生理稳定性和生物相容性。当用808 nm激光照射时，BFO NCs在第二近红外区域也呈现出高荧光发射。有趣的是，BFO NCs表现出高效的US增强羟基自由基生成，因为US产生的空化气泡引发了部分严重湍流并促进了芬顿试剂的转移速率。因此，BFO NCs能够在外部US辅助下有效抑制肿瘤生长，并且可以通过计算机断层扫描、磁共振和荧光成像来监测治疗效果。同时，HO和US作为双逻辑门，激活BFO NCs以触发具有高特异性和治疗效率的铁催化和US增强的CDT。因此，提出了BFO NCs作为一种具有外部US辅助增强化学动力治疗效果和多模态成像能力的诊疗剂，其在无创化学动力肿瘤治疗方面显示出有前景的前景。
