摩洛哥特有植物（Matthiola maroccana Coss.）对正常和链脲佐菌素诱导的糖尿病大鼠具有显著的降血糖作用。
Potent Antihyperglycemic Effect of an Endemic Plant from Morocco (Matthiola Maroccana Coss.) on Normal and Streptozotocin-Induced Diabetic Rats.
机构信息
Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco.
出版信息
Endocr Metab Immune Disord Drug Targets. 2021;21(3):434-440. doi: 10.2174/1871530320666200520095305.
BACKGROUND
Matthiola maroccana (Coss.) belongs to the Brassicaceae family and it is an endemic plant from Morocco.
OBJECTIVE
The objective of the study was to evaluate the effect of aqueous extract of Matthiola maroccana (Coss.) on blood glucose levels in normal and diabetic rats.
METHODS
The effect of single dose (6 hours) and daily oral administration for seven days of the Aerial Part Aqueous Extract (A.P.A.E) of Matthiola maroccana (Coss.) (M. maroccana) at a dose of 20 mg/kg body weight on blood glucose levels in normal and streptozotocin(STZ)-induced diabetic rats was observed. Furthermore, body weight, oral glucose tolerance test, liver histopathological examination, phytochemical screening, and in vitro antioxidant activity of A.P.A.E were evaluated in this study.
RESULTS
The results showed that M. maroccana A.P.A.E exerts potent hypoglycemic and antihyperglycemic effects on normal and STZ-induced diabetic rats (p<0.0001). Also, it was able to restore body weight in diabetic rats (p<0.05). Furthermore, the aqueous extract has been shown to regenerate hepatic tissues in diabetic rats. Besides, A.P.A.E revealed the presence of several phytochemical constituents (polyphenols, flavonoids, tannins, saponins, alkaloids, sterols and terpenoids), and possessed antioxidant activity.
CONCLUSION
In conclusion, our findings showed that A.P.A.E of M. maroccana (A.P.A.E MM) possesses significant antihyperglycemic and hypoglycemic activities.
背景
摩洛哥堇菜（Coss.）属于十字花科，是摩洛哥特有的植物。
目的
本研究旨在评估摩洛哥堇菜水提物对正常和糖尿病大鼠血糖水平的影响。
方法
观察单次剂量（6 小时）和连续 7 天每天口服 20mg/kg 体重的摩洛哥堇菜地上部分水提物（A.P.A.E）对正常和链脲佐菌素（STZ）诱导的糖尿病大鼠血糖水平的影响。此外，还评估了 A.P.A.E 的体重、口服葡萄糖耐量试验、肝组织病理学检查、植物化学成分筛选和体外抗氧化活性。
结果
结果表明，摩洛哥堇菜 A.P.A.E 对正常和 STZ 诱导的糖尿病大鼠具有显著的降血糖和抗高血糖作用（p<0.0001）。此外，它还能够恢复糖尿病大鼠的体重（p<0.05）。此外，水提物已显示出能够在糖尿病大鼠中再生肝组织。此外，A.P.A.E 含有多种植物化学成分（多酚、类黄酮、单宁、皂苷、生物碱、甾醇和萜类化合物），具有抗氧化活性。
结论
总之，我们的研究结果表明，摩洛哥堇菜 A.P.A.E 具有显著的降血糖和降血糖作用。
Zotero 插件