Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Danish Technological institute, Taastrup, Denmark.
BMC Vet Res. 2020 May 20;16(1):148. doi: 10.1186/s12917-020-02369-5.
Infection in the oviduct (salpingitis) is the most common bacterial infection in egg laying hens and is mainly caused by Escherichia coli. The disease is responsible for decreased animal welfare, considerable economic loss as well as a risk of horizontal and vertical transmission of pathogenic E. coli. The outcome of salpingitis may be either acute or chronic. It has not yet been clarified whether the pathological manifestation is a result of the characteristics of the E. coli or whether the manifestation is associated with host factors such as host immunity.
From the core- and accessory genome analysis and comparison of 62 E. coli no genetic markers were found to be associated to either acute or chronic infection. Twenty of the 62 genomes harboured at least one antimicrobial resistance gene with resistance against sulfonamides being the most common. The increased serum survival and iron chelating genes iss and iroN were highly prevalent in genomes from both acute and chronic salpingitis.
Our analysis revealed that no genetic markers could differentiate the E. coli isolated from acute versus chronic salpingitis in egg laying hens. The difference in pathological outcome may be related to other factors such as immunological status, genetics and health of the host. These data indicate that salpingitis is another manifestation of colibacillosis.
输卵管感染（输卵管炎）是产蛋母鸡最常见的细菌性感染，主要由大肠杆菌引起。该疾病导致动物福利下降，造成巨大的经济损失，并存在致病性大肠杆菌水平和垂直传播的风险。输卵管炎的结局可为急性或慢性。输卵管炎的病理表现是由大肠杆菌的特性引起，还是与宿主免疫等宿主因素有关，目前尚不清楚。
对 62 株大肠杆菌的核心和辅助基因组进行分析和比较，没有发现与急性或慢性感染相关的遗传标记。在 62 个基因组中，有 20 个至少携带一个对抗生素有耐药性的基因，对磺胺类药物的耐药性最为常见。血清存活和铁螯合基因 iss 和 iroN 在急性和慢性输卵管炎的基因组中高度流行。
我们的分析表明，从急性和慢性输卵管炎分离的大肠杆菌之间没有遗传标记可以区分。病理结果的差异可能与宿主的免疫状态、遗传和健康等其他因素有关。这些数据表明输卵管炎是大肠杆菌病的另一种表现形式。
