Hyttel Poul, de Figueiredo Pessôa Laís Vicari, Secher Jan Bojsen-Møller, Dittlau Katarina Stoklund, Freude Kristine, Hall Vanessa J, Fair Trudee, Assey Remmy John, Laurincik Jozef, Callesen Henrik, Greve Torben, Stroebech Lotte Björg
Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark.
Department of Veterinary Clinical Sciences, University of Copenhagen, Denmark.
Anim Reprod. 2019 Oct 23;16(3):508-523. doi: 10.21451/1984-3143-AR2019-0054.
The veterinary and animal science professions are rapidly developing and their inherent and historical connection to agriculture is challenged by more biomedical and medical directions of research. While some consider this development as a risk of losing identity, it may also be seen as an opportunity for developing further and more sophisticated competences that may ultimately feed back to veterinary and animal science in a synergistic way. The present review describes how agriculture-related studies on bovine embryo production through studies of putative bovine and porcine embryonic stem cells led the way to more sophisticated studies of human induced pluripotent stem cells (iPSCs) using e.g. gene editing for modeling of neurodegeneration in man. However, instead of being a blind diversion from veterinary and animal science into medicine, these advanced studies of human iPSC-derived neurons build a set of competences that allowed us, in a more competent way, to focus on novel aspects of more veterinary and agricultural relevance in the form of porcine and canine iPSCs. These types of animal stem cells are of biomedical importance for modeling of iPSC-based therapy in man, but in particular the canine iPSCs are also important for understanding and modeling canine diseases, as e.g. canine cognitive dysfunction, for the benefit and therapy of dogs.
兽医和动物科学专业正在迅速发展，它们与农业固有的历史联系正受到更多生物医学和医学研究方向的挑战。虽然有些人认为这种发展存在失去自身特性的风险，但它也可被视为一个发展更先进、更复杂能力的机会，这些能力最终可能以协同的方式反馈到兽医和动物科学领域。本综述描述了通过对假定的牛和猪胚胎干细胞的研究，与农业相关的牛胚胎生产研究如何引领了对人类诱导多能干细胞（iPSC）进行更复杂研究的道路，例如使用基因编辑对人类神经退行性疾病进行建模。然而，对人类iPSC衍生神经元的这些高级研究并非是从兽医和动物科学盲目转向医学，而是构建了一系列能力，使我们能够以更有能力的方式，以猪和犬iPSC的形式关注更多与兽医和农业相关的新方面。这些类型的动物干细胞对于人类基于iPSC的治疗建模具有生物医学重要性，但特别是犬iPSC对于理解和模拟犬类疾病（如犬认知功能障碍）也很重要，有助于犬类的健康和治疗。
