Quaglio Deborah, Corradi Silvia, Erazo Silvia, Vergine Valeria, Berardozzi Simone, Sciubba Fabio, Cappiello Floriana, Crestoni Maria Elisa, Ascenzioni Fiorentina, Imperi Francesco, Delle Monache Franco, Mori Mattia, Loffredo Maria Rosa, Ghirga Francesca, Casciaro Bruno, Botta Bruno, Mangoni Maria Luisa
Department of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Center For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena, 291, 00161 Rome, Italy.
ACS Med Chem Lett. 2020 Jan 30;11(5):760-765. doi: 10.1021/acsmedchemlett.9b00605. eCollection 2020 May 14.
Novel diterpenoids were isolated from the extracts of var. and found to display a selective activity against Gram-positive bacterial strains with negligible cytotoxicity toward human keratinocytes. This study highlighted the role played by the acidic group at C18 of the tetracyclic ent-beyerene scaffold for antibacterial effects and how the length and flexibility of the alkyl chain between the two carbonyl groups are crucial factors to increase the antimicrobial activity of the molecules, supporting the development of natural products from and their derivatives for treatment of microbial infections.
从[植物名称]变种的提取物中分离出新型二萜类化合物，发现它们对革兰氏阳性细菌菌株具有选择性活性，而对人角质形成细胞的细胞毒性可忽略不计。这项研究强调了四环对映贝壳杉烯骨架C18位酸性基团在抗菌作用中所起的作用，以及两个羰基之间烷基链的长度和柔韧性是提高分子抗菌活性的关键因素，为开发[植物名称]及其衍生物用于治疗微生物感染的天然产物提供了支持。
