Maj Institute of Pharmacology Polish Academy of Sciences, Department of Drug Addiction Pharmacology, Smętna Street 12, 31-343 Kraków, Poland.
Nutrients. 2020 May 19;12(5):1462. doi: 10.3390/nu12051462.
Recent studies have emphasized the role of the maternal diet in the development of mental disorders in offspring. Substance use disorder is a major global health and economic burden. Therefore, the search for predisposing factors for the development of this disease can contribute to reducing the health and social damage associated with addiction. In this study, we focused on the impact of the maternal diet on changes in melanocortin-4 (MC-4) receptors as well as on behavioral changes related to cocaine addiction. Rat dams consumed a high-fat diet (HFD), high-sugar diet (HSD, rich in sucrose), or mixed diet (MD) during pregnancy and lactation. Using an intravenous cocaine self-administration model, the susceptibility of female offspring to cocaine reward and cocaine-seeking propensities was evaluated. In addition, the level of MC-4 receptors in the rat brain structures related to cocaine reward and relapse was assessed. Modified maternal diets did not affect cocaine self-administration in offspring. However, the maternal HSD enhanced cocaine-seeking behavior in female offspring. In addition, we observed that the maternal HSD and MD led to increased expression of MC-4 receptors in the nucleus accumbens, while increased MC-4 receptor levels in the dorsal striatum were observed after exposure to the maternal HSD and HFD. Taken together, it can be concluded that a maternal HSD is an important factor that triggers cocaine-seeking behavior in female offspring and the expression of MC-4 receptors.
最近的研究强调了母体饮食在后代精神障碍发展中的作用。物质使用障碍是一个主要的全球健康和经济负担。因此，寻找导致这种疾病发展的易患因素可以有助于减少与成瘾相关的健康和社会损害。在这项研究中，我们专注于母体饮食对黑色素皮质素-4 (MC-4) 受体变化以及与可卡因成瘾相关的行为变化的影响。妊娠和哺乳期的母鼠摄入高脂肪饮食（HFD）、高糖饮食（HSD，富含蔗糖）或混合饮食（MD）。使用静脉内可卡因自我给药模型，评估雌性后代对可卡因奖赏和可卡因寻求倾向的易感性。此外，评估了与可卡因奖赏和复发相关的大鼠脑结构中 MC-4 受体的水平。改良的母体饮食不会影响后代的可卡因自我给药。然而，母体 HSD 增强了雌性后代的可卡因寻求行为。此外，我们观察到母体 HSD 和 MD 导致伏隔核中 MC-4 受体表达增加，而暴露于母体 HSD 和 HFD 后，背侧纹状体中的 MC-4 受体水平增加。综上所述，可以得出结论，母体 HSD 是触发雌性后代可卡因寻求行为和 MC-4 受体表达的重要因素。
