De Vitis Rocco, Passiatore Marco, Perna Andrea, Starnoni Marta, Taccardo Giuseppe
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
Università Cattolica del Sacro Cuore, Roma, Italia.
Plast Reconstr Surg Glob Open. 2020 Apr 27;8(4):e2754. doi: 10.1097/GOX.0000000000002754. eCollection 2020 Apr.
Ledderhose disease (LD) is a rare plantar fibromatosis of the foot, frequently associated with Dupuytren disease. Collagenase of has recently revolutionized the way to treat Dupuytren disease. Nevertheless, the literature is still critically lacking about the use of collagenase injection in LD. We report a case of a man with bilateral symptomatic LD treated with collagenase. Injections (0.58 mg of collagenase of ) were performed into nodules. Forced extension after injection was not performed. The patient could walk normally immediately after procedure. The procedure was a complete success without side effects or complications on either foot. Currently, at 14 months after treatment of the right foot and 12 months after treatment of the left foot, no recurrence has been observed. Collagenase injection was only effective in treating symptomatic LD in this one patient we reported on.
莱德霍斯病（LD）是一种罕见的足部足底纤维瘤病，常与掌腱膜挛缩症相关。胶原酶最近彻底改变了治疗掌腱膜挛缩症的方法。然而，关于胶原酶注射治疗LD的文献仍然严重匮乏。我们报告一例用胶原酶治疗双侧有症状LD的男性病例。将（0.58毫克的）胶原酶注射到结节中。注射后未进行强制伸展。患者术后可立即正常行走。该手术完全成功，双脚均无副作用或并发症。目前，右脚治疗后14个月和左脚治疗后12个月，均未观察到复发。在我们报告的这例患者中，胶原酶注射仅对治疗有症状的LD有效。
