Mahmoud Arin, Kozhikunnath Arun, Buddhdev Pranai
Trauma and Orthopaedic Department, Broomfield Hospital, Chelmsford, UK.
J Surg Case Rep. 2021 Feb 28;2021(2):rjaa501. doi: 10.1093/jscr/rjaa501. eCollection 2021 Feb.
Ledderhose disease is a connective tissue disorder involving proliferation of fibrous tissue in the plantar fascia of the foot. Histologically identical manifestations exist in the hand (Dupuytren's contracture) and penis (Peyronie's disease), and collagenase injections are approved as a treatment in both, however not in Ledderhose, where the treatment of choice remains surgical resection. Surgery is associated with high rates of recurrence and need for further surgery, so alternative therapies should be sought. Due to their histological and physiological similarities, it is likely that therapies useful in Dupuytren's and Peyronie's would be useful in Ledderhose. Two previous case reports investigating collagenase injections for Ledderhose disease in adults have shown conflicting results; this study demonstrates the efficacy of collagenase injections in a paediatric patient at 1-year follow-up.
莱德霍斯病是一种结缔组织疾病，涉及足部跖腱膜纤维组织的增生。手部（杜普伊特伦挛缩症）和阴茎（佩罗尼氏病）存在组织学上相同的表现，胶原酶注射被批准用于这两种疾病的治疗，但在莱德霍斯病中未获批准，该病的首选治疗方法仍是手术切除。手术复发率高且需要进一步手术，因此应寻求替代疗法。由于它们在组织学和生理学上的相似性，对杜普伊特伦挛缩症和佩罗尼氏病有效的疗法可能对莱德霍斯病也有用。之前两项针对成人莱德霍斯病胶原酶注射的病例报告结果相互矛盾；本研究证明了胶原酶注射在一名儿科患者1年随访中的疗效。
