Department of Health Sciences, University of Milan, Milan, Italy.
Nutr Neurosci. 2022 Mar;25(3):441-461. doi: 10.1080/1028415X.2020.1760531. Epub 2020 May 22.
The beneficial effects of many substances have been discovered because of regular dietary consumption. This is also the case with curcumin, whose effects have been known for more than 4,000 years in Eastern countries such as China and India. A curcumin-rich diet has been known to counteract many human diseases, including cancer and diabetes, and has been shown to reduce inflammation. The effect of a curcumin treatment for neurological diseases, such as spinal muscular atrophy; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; multiple sclerosis; and others, has only recently been brought to the attention of researchers and the wider population. In this paper, we summarise the studies on this natural product, from its isolation two centuries ago to its characterisation a century later. We describe its role in the treatment of neurological diseases, including its cellular and common molecular mechanisms, and we report on the clinical trials of curcumin with healthy people and patients. Commenting on the different approaches adopted by the efforts made to increase its bioavailability.
许多物质的有益效果是由于经常食用而被发现的。姜黄素也是如此，它在中国和印度等东方国家已经有 4000 多年的历史，其效果为人所知。富含姜黄素的饮食已被证明可以对抗许多人类疾病，包括癌症和糖尿病，并已被证明具有抗炎作用。姜黄素治疗神经疾病的效果，如脊髓性肌萎缩症、阿尔茨海默病、帕金森病、肌萎缩侧索硬化症、多发性硬化症等，最近才引起研究人员和更广泛人群的关注。在本文中，我们总结了两个世纪前从姜黄素的分离到一个世纪后的特性描述的研究。我们描述了它在治疗神经疾病中的作用，包括其细胞和常见的分子机制，并报告了姜黄素在健康人群和患者中的临床试验。评论了为提高其生物利用度而采取的不同方法。
