Department of Oral Surgery, Leeds University School of Dentistry, Worsley Building, Clarendon Way, Leeds, LS2 9LU, UK.
Br Dent J. 2020 May;228(10):795-799. doi: 10.1038/s41415-020-1540-8.
In today's global market, there is a very wide range of fluoride toothpastes varying in formulation, fluoride concentration, quality control of ingredients and manufacture, and some products are transported, stored and sold to consumers in countries far removed from where they are made. The competitiveness of the toothpaste market has driven the major manufacturers to offer an increasing and frequently changing variety of formulations to support claims of caries prevention, tooth whitening, sensitivity prevention, gum health and total oral health. However, the focus of this article is to consider how variations in formulation and the fluoride content of toothpastes might affect clinical efficacy for caries prevention. On the basis of presently available evidence, it would appear that the most reliable indicator of the effective fluoride content for a toothpaste formulation is the ionic fluoride concentration (F) as parts per million (ppm) available immediately on brushing. However, as the recent international workshop on testing methods concluded, the clinical validation, acceptance and agreement of standardised testing methods by both manufacturers and international bodies would be required. If these technical difficulties can be overcome and all manufacturers standardised on this form of expression and did not declare the total, soluble or free ionic fluoride as calculated on a theoretical basis, then it would provide a more meaningful indicator that dental professionals, pharmacies and indeed the consumer could rely upon.
在当今的全球市场上，有各种各样的氟化物牙膏，其配方、氟化物浓度、成分质量控制和制造各不相同，有些产品在远离制造地的国家运输、储存和销售给消费者。牙膏市场的竞争力促使各大制造商提供越来越多且经常变化的各种配方，以支持防龋、牙齿美白、预防敏感、牙龈健康和整体口腔健康的功效宣称。然而，本文的重点是考虑牙膏配方的变化和氟化物含量如何影响防龋的临床效果。根据目前现有的证据，似乎最能可靠地表明牙膏配方有效氟化物含量的是离子氟浓度（F），以百万分之几（ppm）表示，在刷牙后立即可用。然而，正如最近的国际测试方法研讨会上得出的结论，需要制造商和国际机构对标准化测试方法进行临床验证、认可和同意。如果这些技术难题能够克服，并且所有制造商都采用这种表达方式，而不是根据理论计算来声明总氟化物、可溶性氟化物或游离离子氟化物，那么这将提供一个更有意义的指标，供牙医、药剂师甚至消费者信赖。
