市售漱口水中的氟化物、pH 值和可滴定酸度。

Fluoride, pH Value, and Titratable Acidity of Commercially Available Mouthwashes.

机构信息

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands; Department of Dental Hygiene, Hogeschool Arnhem Nijmegen, University of Applied Sciences, Nijmegen, The Netherlands.

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, The Netherlands.

出版信息

Int Dent J. 2024 Apr;74(2):260-267. doi: 10.1016/j.identj.2023.09.002. Epub 2023 Oct 13.

DOI:10.1016/j.identj.2023.09.002

PMID:37839955

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10988266/

Abstract

AIM

The primary objective of this work was to assess total soluble fluoride (TSF), pH values, and titratable acidity (TA) of various mouthwashes "in vitro," and the second was to compare fluoride content on labels with measured TSF.

METHODS

Commercial mouthwashes were collected and analysed. Company, type, manufacturer data, and active ingredients (essential oils [EO], cetylpyridinium chloride [CPC], chlorhexidine [CHX], and fluoride) were described. TSF, pH, and TA capacity were measured. Descriptive quantitative analysis were performed per mouthwash.

RESULTS

In total, 54 mouthwashes from 20 brands were included. These included mouthwashes with the active ingredients EO (n = 11), CPC (n = 17), CHX (n = 18), and fluoride (n = 32); 27 mouthwashes with more than 1 of these active ingredients; and 4 with none of the above-mentioned ingredients. Fluoride was present in different formulations; most contained sodium fluoride (NaF), and a few had sodium monofluorophosphate and amine fluoride + NaF. The pH values of all evaluated mouthwashes ranged from 4.1 to 7.9. Twenty mouthwashes presented pHs below 5.5, of which 10 contained fluoride. TA ranged from 0 to 48. According to the manufacturer data, mouthwashes with fluoride had concentrations from 217 to 450 ppm, with 90% in the range from 217 to 254 ppm. Laboratory data revealed that TSF ranged from 229 to 500 ppm, with 90% in the range from 229 to 337 ppm. A statistically significant difference was observed between measured TSF and the labelled fluoride content on the packaging of the fluoride mouthwashes (mean difference, 43.92 ± 34.34; P < .001). Most of these mouthwashes contained at least the amount of fluoride as mentioned on the packaging (93%).

CONCLUSION

The pH values and TA of commercially available mouthwashes showed a large variation. TSF levels of the fluoride mouthwashes were found to be at least the amount of fluoride as labelled. Dental care professionals should be aware of the pH, TA, fluoride content, and other active ingredients of different mouthwashes to better understand their potential impact on oral health.

摘要

目的

本研究的主要目的是评估各种市售漱口水的总可溶氟（TSF）、pH 值和滴定酸度（TA），并比较标签上的氟化物含量与实测 TSF 值。

方法

收集和分析市售漱口水。描述了公司、类型、制造商数据以及活性成分（精油[EO]、十六烷基吡啶氯[CPC]、洗必泰[CHX]和氟化物）。测量 TSF、pH 和 TA 容量。按漱口水进行描述性定量分析。

结果

共纳入 20 个品牌的 54 种漱口水。这些漱口水的活性成分包括 EO（n=11）、CPC（n=17）、CHX（n=18）和氟化物（n=32）；27 种含有上述一种以上的漱口水；4 种不含上述任何成分的漱口水。氟化物以不同配方存在；大多数含氟化钠（NaF），少数含单氟磷酸钠和胺氟化物+NaF。所有评估的漱口水的 pH 值范围为 4.1 至 7.9。20 种漱口水中 pH 值低于 5.5，其中 10 种含氟化物。TA 范围为 0 至 48。根据制造商数据，含氟漱口水的浓度为 217 至 450ppm，90%的浓度在 217 至 254ppm 之间。实验室数据显示，TSF 范围为 229 至 500ppm，90%的浓度在 229 至 337ppm 之间。含氟漱口水的实测 TSF 与包装上的标签氟化物含量之间存在统计学显著差异（平均差异，43.92±34.34；P<.001）。这些漱口水大多数都含有包装上标注的氟化物量（93%）。