Kim Hyunjin, Lim Young-Min, Kim Geonwoo, Lee Eun-Jae, Lee Jeong Hyun, Kim Hye Weon, Kim Kwang-Kuk
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
J Neurol Sci. 2020 Aug 15;415:116904. doi: 10.1016/j.jns.2020.116904. Epub 2020 May 15.
To investigate alterations in the choroid plexus in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using brain magnetic resonance imaging (MRI).
We prospectively recruited consecutive patients with MS or NMOSD from July 2018 to February 2019. The inclusion criterion was brain MRI within three months from onset of acute neurological symptoms. The thickness and enhancement ratio of the choroid plexus on gadolinium-enhanced T1-weighted images of patients with MS (n = 51), patients with NMOSD (n = 32), and healthy controls (HCs, n = 28) were compared.
MRI in patients with MS or NMOSD showed a comparably thick but more enhanced choroid plexus compared with that of HCs. In the axial view, enhancement ratios of the lateral ventricle of MS and NMOSD patients and HCs were 1.64 ± 0.34, 1.65 ± 0.25, and 1.39 ± 0.17, respectively (P > .999 for MS vs. NMOSD; P = .001 for MS vs. HCs; P = .001 for NMOSD vs. HCs).
The choroid plexus was significantly more enhanced on brain MRI of patients with MS or NMOSD than on that of HCs, suggesting the involvement of the choroid plexus in the autoimmune inflammatory processes in MS and NMOSD.
使用脑磁共振成像（MRI）研究多发性硬化症（MS）和视神经脊髓炎谱系障碍（NMOSD）中脉络丛的变化。
我们前瞻性地招募了2018年7月至2019年2月期间连续的MS或NMOSD患者。纳入标准为急性神经症状发作后三个月内的脑MRI。比较了MS患者（n = 51）、NMOSD患者（n = 32）和健康对照者（HCs，n = 28）钆增强T1加权图像上脉络丛的厚度和强化率。
与HCs相比，MS或NMOSD患者的MRI显示脉络丛厚度相当，但强化更明显。在轴位视图中，MS和NMOSD患者及HCs侧脑室的强化率分别为1.64±0.34、1.65±0.25和1.39±0.17（MS与NMOSD相比，P>.999；MS与HCs相比，P = .001；NMOSD与HCs相比，P = .001）。
MS或NMOSD患者脑MRI上脉络丛的强化明显高于HCs，提示脉络丛参与了MS和NMOSD的自身免疫炎症过程。
