Berner B, Wilson D R, Guy R H, Mazzenga G C, Clarke F H, Maibach H I
CIBA-GEIGY, Ardsley, New York 10502.
Pharm Res. 1988 Oct;5(10):660-3. doi: 10.1023/a:1015931105660.
The relationship between pKa and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15-88 micrograms/cm2/hr). Skin irritation and pKa are correlated for pKa less than or equal to 4. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pKa; erythema at 24 hr appears to be the most sensitive parameter to variation in pKa when pKa less than or equal to 4.
针对一系列苯甲酸衍生物研究了其pKa与人皮肤刺激性之间的关系，这些衍生物以相当的速率（15 - 88微克/平方厘米/小时）透过人体皮肤。当pKa小于或等于4时，皮肤刺激性与pKa相关。用激光多普勒测速仪评估皮肤血流、用色度计读数、红斑、水肿以及原发性刺激指数均呈线性相关且与pKa有关；当pKa小于或等于4时，24小时时的红斑似乎是对pKa变化最敏感的参数。
