Bucher K, Bucher K E, Walz D
Agents Actions. 1981 Nov;11(5):515-9. doi: 10.1007/BF02004715.
The paper describes a method for judging the irritative potentialities of substances; proposes a scoring system with which the 'ordinary' risks of many of the abundant marketed products for washing, cleaning etc. may be predicted without biological testing; discusses pharmacodynamic and pharmacokinetic aspects of topical irritancy and points to the problems of extrapolating from animal experiments to man.
本文描述了一种判断物质刺激性潜能的方法；提出了一种评分系统，利用该系统无需进行生物测试即可预测许多市售洗涤、清洁等产品的“常规”风险；讨论了局部刺激性的药效学和药代动力学方面，并指出了从动物实验推断至人体存在的问题。
