Department of General Pathology, Biological Sciences Center, State University of Londrina, 86057-970, Londrina, PR, Brazil.
Cancer Hospital of Londrina, Londrina, PR, Brazil.
J Cancer Res Clin Oncol. 2020 Aug;146(8):1971-1978. doi: 10.1007/s00432-020-03256-0. Epub 2020 May 23.
Interleukin-10 (IL-10) is an immunoregulatory cytokine and its cervical and serum concentrations have been associated with a poor prognosis of cervical cancer. The rs1800872 polymorphism (c.-592C>A) in the promotor region of the IL-10 gene affects the production and expression of IL-10 and thus is able to determine the immune response profile in the cervix. Therefore, the aim of this work is to state the association between IL-10 c.-592C>A polymorphism and cervical cancer.
Genomic DNA was extracted from patient's peripheral blood and tumor biopsy. Socio-demographic, sexual behavior and reproductive characteristics data were collected using a questionnaire.
Co-dominant model in logistic binary regression adjusted for confounders, showed that patients presenting with C/A genotype had 2.15 times more chances for developing cervical cancer (OR 2.15; CI 1.02-4.56). The dominant model, C/A + A/A, was also independently associated with 2.71 times more chances for cervical cancer development when compared to control patients (OR 2.71; CI 1.05-4.47).
Our study analyses show the association between cervical cancer and IL-10 c.-592C>A polymorphism, demonstrating that the allele A presence was independently associated with higher risks of cervical cancer development.
白细胞介素-10（IL-10）是一种免疫调节细胞因子，其宫颈和血清浓度与宫颈癌的预后不良有关。IL-10 基因启动子区域的 rs1800872 多态性（c.-592C>A）影响 IL-10 的产生和表达，从而能够决定宫颈的免疫反应特征。因此，本研究旨在阐明 IL-10 c.-592C>A 多态性与宫颈癌之间的关系。
从患者外周血和肿瘤活检中提取基因组 DNA。使用问卷收集社会人口统计学、性行为和生殖特征数据。
在调整混杂因素的逻辑二元回归的共显性模型中，携带 C/A 基因型的患者发生宫颈癌的几率增加了 2.15 倍（OR 2.15；95%CI 1.02-4.56）。与对照患者相比，显性模型 C/A+A/A 也与宫颈癌发展的几率增加 2.71 倍独立相关（OR 2.71；95%CI 1.05-4.47）。
我们的研究分析表明，宫颈癌与 IL-10 c.-592C>A 多态性之间存在关联，表明等位基因 A 的存在与宫颈癌发展的风险增加独立相关。
