NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Basic Medical Sciences, Fudan University, 2140 Xietu road, Xuhui district, Shanghai, China.
Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China.
J Autism Dev Disord. 2021 Jan;51(1):267-275. doi: 10.1007/s10803-020-04543-y.
In this study, we tested the feces of children with ASD and those of healthy children, and the overall changing of the gut fungal community was observed in ASD children compared with controls. However, there were no abundant fungi populations showed significant variations between the ASD and Control group both at phylum and class level. Among the 507 genera identified, Saccharomyces and Aspergillus showed significant differences between ASD (59.07%) and Control (40.36%), indicating that they may be involved in the abnormal gut fungal community structure of ASD. When analyzed at the species level, a decreased abundance in Aspergillus versicolor was observed while Saccharomyces cerevisiae was increased in children with ASD relative to controls. Overall, this study characterized the fungal microbiota profile of children with ASD and identified potential diagnostic species closely related to the immune response in ASD.
在这项研究中，我们检测了自闭症谱系障碍儿童和健康儿童的粪便样本，结果显示，与对照组相比，自闭症谱系障碍儿童的肠道真菌群落整体发生了变化。然而，在门和纲水平上，自闭症谱系障碍组和对照组之间并没有丰富的真菌种群表现出显著差异。在鉴定出的 507 个属中，酿酒酵母属和曲霉菌属在自闭症谱系障碍组（59.07%）和对照组（40.36%）之间存在显著差异，表明它们可能参与了自闭症谱系障碍异常肠道真菌群落结构的形成。在种水平上分析时，与对照组相比，自闭症谱系障碍儿童体内的鲜绿青霉的丰度降低，而酿酒酵母的丰度增加。总的来说，这项研究描绘了自闭症谱系障碍儿童的真菌微生物组图谱，并鉴定出了与自闭症谱系障碍免疫反应密切相关的潜在诊断物种。
