自闭症儿童肠道微生物群的荟萃分析。
A Meta-analysis of Gut Microbiota in Children with Autism.
作者信息
Andreo-Martínez Pedro, Rubio-Aparicio María, Sánchez-Meca Julio, Veas Alejandro, Martínez-González Agustín Ernesto
机构信息
Department of Agricultural Chemistry, Faculty of Chemistry, University of Murcia, Campus of Espinardo, Murcia, Spain.
Department of Chemical Engineering, Faculty of Chemistry, University of Murcia, Campus of Espinardo, Murcia, Spain.
出版信息
J Autism Dev Disord. 2022 Mar;52(3):1374-1387. doi: 10.1007/s10803-021-05002-y. Epub 2021 May 5.
Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD = - 0.999; 95% CI - 1.549, - 0.449) and Bifidobacterium genera (SMD = - 0.513; 95% CI - 0.953, - 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.
先前的研究报告称，自闭症谱系障碍（ASD）儿童的肠道微生物群（GM）存在生态失调，这可能是通过微生物群-肠道-脑轴影响儿童发育的一个决定性因素。然而，尚不清楚ASD中是否存在一组特定的生态失调细菌。本研究的目的是对分析ASD儿童GM的研究进行荟萃分析。18项研究符合我们的选择标准。我们的结果显示，ASD儿童中链球菌属（标准化均数差[SMD]= -0.999；95%置信区间[-1.549，-0.449]）和双歧杆菌属（SMD = -0.513；95%置信区间[-0.953，-0.073]）的相对丰度较低。总体而言，双歧杆菌属参与其中。然而，研究之间发现的差异归因于报告偏倚等因素。
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