Public Health Program, Department of Health Sciences, European University, Diogenis Str 6, 2404, Nicosia, Cyprus.
School of Sciences and Engineering, Pharmacy School, Pharmacoepidemiology-Pharmacovigilance, University of Nicosia, Makedonitissis 46, 2417, Nicosia, Cyprus.
Clin Rheumatol. 2020 Dec;39(12):3571-3579. doi: 10.1007/s10067-020-05122-3. Epub 2020 May 24.
To assess and update the effect of the combination of vitamin D and calcium in the reduction of osteoporotic fractures, a systematic review across Cochrane Database, NIHR HTA database, PubMed and Google Scholar was performed using mesh terms : Cohort studies OR Prospective Studies OR Longitudinal Studies OR Follow-Up Studies OR Incidence OR Risk OR Rate and Osteoporotic Fractures OR Fractures, Bone OR Fractures, Spontaneous OR Spinal Fractures OR Humeral Fractures OR Hip Fractures OR Femoral Neck Fractures AND Vitamin D AND Calcium and key words: vitamin D, fractures, osteoporosis, calcium, dietary supplements. Statistical analysis was performed with Review Manager (RevMan 5.3) using relative risk and confidence interval 95%. The combination reduced total fractures and hip fractures while no effect was observed in wrist fractures. The combination was also well tolerated. Only minor side effects were reported. This systematic review suggests that the combination of vitamin D and calcium can exert a beneficial effect towards osteoporotic fracture reduction.
为了评估和更新维生素 D 和钙联合用于减少骨质疏松性骨折的效果，我们对 Cochrane 数据库、NIHR HTA 数据库、PubMed 和 Google Scholar 进行了系统评价，使用了主题词：队列研究或前瞻性研究或纵向研究或随访研究或发病率或风险或速率和骨质疏松性骨折或骨骨折或自发性骨折或脊柱骨折或肱骨骨折或髋部骨折或股骨颈骨折和维生素 D 和钙，并使用关键词：维生素 D、骨折、骨质疏松症、钙、膳食补充剂。使用 Review Manager（RevMan 5.3）进行统计分析，使用相对风险和 95%置信区间。联合使用可减少总体骨折和髋部骨折，但对手腕骨折无影响。联合使用也具有良好的耐受性。仅报告了轻微的副作用。这项系统评价表明，维生素 D 和钙的联合使用可以对骨质疏松性骨折的减少产生有益的效果。
