School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
J Asian Nat Prod Res. 2021 Aug;23(8):745-753. doi: 10.1080/10286020.2020.1769610. Epub 2020 May 25.
Ten thiophene derivatives (1-10), including two previously undescribed ones (1 and 2), have been obtained and structurally characterized from the aerial parts of a traditional Chinese herb . Six of them with one chiral center were identified to be scalemic mixtures, and the pure enantiomers of two isolates (1 and 3) were successfully separated via chemical derivatization and chiral HPLC, with the absolute configurations being established by analysis of optical rotations. All the thiophenes were subjected to a series of assays and compounds 9 and 10 exhibited mild antibacterial activity against .[Formula: see text].
从一种传统的中国草药的地上部分中获得并结构鉴定了 10 种噻吩衍生物（1-10），包括两种以前未描述的噻吩（1 和 2）。其中 6 种具有一个手性中心，被鉴定为外消旋混合物，两种分离物（1 和 3）的纯对映异构体通过化学衍生化和手性 HPLC 成功分离，通过分析旋光度确定了绝对构型。所有噻吩都进行了一系列的测定，化合物 9 和 10 对 显示出温和的抗菌活性。
