Kim Ha-Yeong, Kim Hye Mi, Ryu Byeol, Lee Jae-Seung, Choi Jung-Hye, Jang Dae Sik
Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea.
College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Arch Pharm Res. 2015 Nov;38(11):1963-9. doi: 10.1007/s12272-015-0599-2. Epub 2015 Apr 9.
A new terthiophene, 3'-hydroxy-2,2':5',2″-terthiophene-3'-O-β-D-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-β-D-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2-6), seven triterpenoids (8-14), two coumestans (15 and 16), and four flavonoids (17-20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1-20 were evaluated for their cytotoxicity against human ovarian cancer cells (SKOV3) using MTT assays.
从鳢肠地上部分分离得到一个新的三联噻吩，即3'-羟基-2,2':5',2″-三联噻吩-3'-O-β-D-吡喃葡萄糖苷（1）和一个新的齐墩果烷型皂苷，即刺囊酸-3-O-(6-O-乙酰基)-β-D-吡喃葡萄糖苷（7）。此外，在本研究的同一过程中还分离得到了五个结构已知的噻吩类化合物（2 - 6）、七个三萜类化合物（8 - 14）、两个香豆雌酚类化合物（15和16）以及四个黄酮类化合物（17 - 20）。采用MTT法对所有分离物1 - 20进行了抗人卵巢癌细胞（SKOV3）的细胞毒性评价。
