Husby G, Bankhurst A D, Williams R C
Arthritis Rheum. 1977 Apr;20(3):785-91. doi: 10.1002/art.1780200304.
Synovial tissues removed at synovectomy from patients with active rheumatoid arthritis (RA) or osteoarthritis (OA) were examined for prostaglandin E (PGE) by immunohistochemical techniques using rabbit antisera specific for PGE. Marked increments of PGE were noted in RA synovia in comparison to OA, with staining concentrated in synovial lining cells, interstitial inflammatory cells, and endothelial cells of blood vessels. A correlation was noted between the degree of synovial lymphocytic infiltrate and the intensity of PGE staining. These studies provide initial cellular localization of PGE in such tissues.
运用针对前列腺素E（PGE）的兔抗血清，采用免疫组织化学技术，对类风湿性关节炎（RA）或骨关节炎（OA）患者滑膜切除术中所获取的滑膜组织进行PGE检测。结果显示，与OA相比，RA滑膜中PGE显著增加，染色集中于滑膜衬里细胞、间质炎性细胞及血管内皮细胞。滑膜淋巴细胞浸润程度与PGE染色强度之间存在相关性。这些研究为此类组织中PGE提供了初步的细胞定位。
