类风湿性关节炎和骨关节炎患者使用氟比洛芬治疗后关节液中前列腺素E水平的变化
Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis.
作者信息
Tokunaga M, Ohuchi K, Yoshizawa S, Tsurufuji S, Rikimaru A, Wakamatsu E
出版信息
Ann Rheum Dis. 1981 Oct;40(5):462-5. doi: 10.1136/ard.40.5.462.
Abstract
The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9.5-1.2 ng/ml and in proportion with the leucocyte count in the joint fluid. A marked decrease of the PGE level was attained with flurbiprofen treatment in 4 patients whose initial PGE levels had been higher than 3.2 ng/ml, while 4 patients with lower PGE levels, namely, 1.4-1.2 ng/ml, did not respond to the drug treatment. In all the OA patients the PGE levels was no higher than 1.5 ng/ml and refractory to the anti-inflammatory therapy.
摘要
采用放射免疫分析法测定了8例类风湿性关节炎（RA）患者和4例骨关节炎（OA）患者在使用氟比洛芬进行抗炎治疗前后膝关节液中前列腺素E（PGE）的水平。抗炎治疗前，RA关节液中PGE水平为9.5 - 1.2 ng/ml，且与关节液中的白细胞计数成正比。在4例初始PGE水平高于3.2 ng/ml的患者中，氟比洛芬治疗使PGE水平显著降低，而4例PGE水平较低（即1.4 - 1.2 ng/ml）的患者对药物治疗无反应。所有OA患者的PGE水平均不高于1.5 ng/ml，且对抗炎治疗无效。
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