Tokunaga M, Ohuchi K, Yoshizawa S, Tsurufuji S, Rikimaru A, Wakamatsu E
Ann Rheum Dis. 1981 Oct;40(5):462-5. doi: 10.1136/ard.40.5.462.
The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9.5-1.2 ng/ml and in proportion with the leucocyte count in the joint fluid. A marked decrease of the PGE level was attained with flurbiprofen treatment in 4 patients whose initial PGE levels had been higher than 3.2 ng/ml, while 4 patients with lower PGE levels, namely, 1.4-1.2 ng/ml, did not respond to the drug treatment. In all the OA patients the PGE levels was no higher than 1.5 ng/ml and refractory to the anti-inflammatory therapy.
采用放射免疫分析法测定了8例类风湿性关节炎（RA）患者和4例骨关节炎（OA）患者在使用氟比洛芬进行抗炎治疗前后膝关节液中前列腺素E（PGE）的水平。抗炎治疗前，RA关节液中PGE水平为9.5 - 1.2 ng/ml，且与关节液中的白细胞计数成正比。在4例初始PGE水平高于3.2 ng/ml的患者中，氟比洛芬治疗使PGE水平显著降低，而4例PGE水平较低（即1.4 - 1.2 ng/ml）的患者对药物治疗无反应。所有OA患者的PGE水平均不高于1.5 ng/ml，且对抗炎治疗无效。
