Moilanen E, Seppälä E, Nissilä M, Vapaatalo H
Agents Actions. 1987 Feb;20(1-2):98-103. doi: 10.1007/BF01965631.
To evaluate further the complex role of prostanoids in rheumatoid arthritis we compared the immunoreactive prostanoid production of healthy and rheumatic synovial cells in a primary cell culture. During the first days in culture the adherent cells from rheumatic synovia produced higher amounts of prostanoids, especially the proinflammatory and immunosuppressive prostaglandin E2 (PGE2), than cells originating from non-inflamed synovia. This difference disappeared within one week culture and was partly explained by altered substrate availability.
为了进一步评估类前列腺素在类风湿性关节炎中的复杂作用，我们在原代细胞培养中比较了健康和风湿性滑膜细胞的免疫反应性类前列腺素生成情况。在培养的最初几天，来自风湿性滑膜的贴壁细胞比来自非炎症滑膜的细胞产生更多的类前列腺素，尤其是促炎和免疫抑制性前列腺素E2（PGE2）。这种差异在一周的培养内消失，部分原因是底物可用性的改变。
