Osorio-Toribio Génesis, Velásquez-Hernández Miriam de J, Mileo Paulo G M, Zárate J Antonio, Aguila-Rosas Javier, Leyva-Gómez Gerardo, Sánchez-Sánchez Roberto, Magaña Jonathan J, Pérez-Díaz Mario Alberto, Lázaro Isabel Abánades, Forgan Ross S, Maurin Guillaume, Lima Enrique, Ibarra Ilich A
Laboratorio de Fisicoquímica y Reactividad de Superficies (LaFReS), Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria.
iScience. 2020 Jun 26;23(6):101156. doi: 10.1016/j.isci.2020.101156. Epub 2020 May 11.
The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).
本研究表明，Sc(III)金属有机框架型MFM-300(Sc)在生理条件（PBS）下稳定，具有生物相容性（对人类皮肤细胞），是一种用于抗氧化剂阿魏酸长期控释（透过人体皮肤）的高效药物载体。在递送过程中，MFM-300(Sc)还保留了阿魏酸的抗氧化药理作用，同时增强了皮肤成纤维细胞的生物保存能力。这些发现为将基于Sc(III)的金属有机框架扩展用作药物递送系统（DDS）铺平了道路。
