马德隆病与肺曲霉病：一例报告及文献综述
Madelung's disease and pulmonary aspergillosis: a case report and literature review.
作者信息
Ma Weijiang, Zhao Xilong, Li Xu, Zang Chenxi, Yang Limin, Wang Yan, Liu Xin
机构信息
Department of Thoracic Surgery, Second Affiliated Hospital of Kunming Medical University, 374th Dianmian Road, Kunming, 650101, China.
Department of Pathology, 920th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Kunming, 652230, China.
出版信息
J Cardiothorac Surg. 2020 May 25;15(1):114. doi: 10.1186/s13019-020-01166-3.
BACKGROUND
Madelung's disease (MD) is a rare disorder of fat metabolism, which is usually associated with diabetes, hyperuricemia, liver disease, nevertheless there is no report of a patient with MD and pulmonary aspergillosis (PA). This article aimed to enhance the awareness of this two diseases and discuss the possible mechanism of the combination of them preliminarily.
CASE PRESENTATION
In this case, we described a 56-year-old male patient with cough, expectoration and dyspnea. His neck has a very peculiar appearance. Chest enhanced CT scan showed there were multiple nodules in both lungs, some of which had cavities and the mediastinal lymph nodes were swollen. Ultrasound scan of the neck showed diffuse hyperplasia of subcutaneous fat in neck and bilateral supraclavicular fossa. Fortunately, after performing pulmonary wedge resection aimed at pathological examination and giving relevant treatments, this patient was finally diagnosed as MD with PA, and his symptoms were significantly relieved.
CONCLUSIONS
MD is rare, the phenomenon that MD combined with PA is rarer. Immune disorder may be the possible mechanism.
背景
马德隆病（MD）是一种罕见的脂肪代谢紊乱疾病，通常与糖尿病、高尿酸血症、肝脏疾病相关，然而尚无MD合并肺曲霉病（PA）患者的报道。本文旨在提高对这两种疾病的认识，并初步探讨它们合并存在的可能机制。
病例介绍
在本病例中，我们描述了一名56岁男性患者，有咳嗽、咳痰和呼吸困难症状。他的颈部外观非常奇特。胸部增强CT扫描显示双肺有多个结节，部分有空洞形成，纵隔淋巴结肿大。颈部超声扫描显示颈部及双侧锁骨上窝皮下脂肪弥漫性增生。幸运的是，在进行旨在病理检查的肺楔形切除并给予相关治疗后，该患者最终被诊断为MD合并PA，其症状明显缓解。
结论
MD罕见，MD合并PA的现象更为罕见。免疫紊乱可能是其可能机制。
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